Eke R A
Am J Trop Med Hyg. 1979 Nov;28(6):1074-5. doi: 10.4269/ajtmh.1979.28.1074.
A 42-year-old hospital worker had a recrudescence of falciparum malaria after chloroquine therapy. Further adequate treatment with chloroquine given orally did not clear the infection. He was then given a combination of sulphadiazine and pyrimethamine, which produced a radical cure. This points to the possibility of chloroquine-resistant Plasmodium falciparum in Nigeria, an African country where this has been thought to be unlikely. Because of this and earlier reports, clinicians should be on the alert to the possibility of chloroquine-resistant P. falciparum in this area, and efforts should be made to establish or reject the presence of malarial parasites resistant to chloroquine in Africa.
一名42岁的医院工作人员在接受氯喹治疗后，恶性疟复发。口服氯喹进一步进行充分治疗未能清除感染。随后给予其磺胺嘧啶和乙胺嘧啶联合用药，实现了根治。这表明在尼日利亚存在对氯喹耐药的恶性疟原虫的可能性，而在这个非洲国家，此前一直认为这种情况不太可能发生。鉴于此以及早期报告，临床医生应警惕该地区存在对氯喹耐药的恶性疟原虫的可能性，并且应努力确定或排除非洲存在对氯喹耐药的疟原虫。
