Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei 230032, Anhui, China.
Maturitas. 2024 Sep;187:108057. doi: 10.1016/j.maturitas.2024.108057. Epub 2024 Jun 20.
To describe the association of handgrip strength asymmetry and weakness with cognitive function among Chinese middle-aged and older adults.
We used data from four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study. Handgrip strength was measured at baseline. Handgrip strength asymmetry was defined on the basis of the ratio of handgrip strength of the non-dominant hand to that of the dominant hand (i.e. non-dominant/dominant): a ratio of <0.9 defined as dominant handgrip strength asymmetry and >1.1 as non-dominant handgrip strength asymmetry. Weakness was defined as a handgrip strength of <28 kg for males or <18 kg for females.
Cognitive function with its two core dimensions (episodic memory and mental status) at each wave was assessed and standardized.
9333 participants (48.3 % female, age 58.2 ± 9.0 years) were included. Non-dominant but not dominant handgrip strength asymmetry was significantly associated with poorer cognitive function at baseline (β = -0.121, -0.092, and -0.132 for mental status, episodic memory, and global cognition, respectively). In longitudinal analyses over 2 years, dominant handgrip strength asymmetry significantly slowed cognitive decline (β = -0.078 and -0.069 for mental status and global cognition, respectively), and non-dominant handgrip strength asymmetry accelerated cognitive decline (β = 0.053 and 0.043 for episodic memory and global cognition, respectively). Weakness was associated with poorer cognitive function at baseline and cognitive decline over 2, 4, and 7 years (all P < 0.05).
In middle-aged and older adults, non-dominant handgrip strength asymmetry and weakness were associated with poorer cognitive function and predicted accelerated cognitive decline. Dominant handgrip strength asymmetry may be beneficial for maintaining cognitive function.
描述中国中老年人群握力不对称和握力弱与认知功能的关系。
我们使用了中国健康与退休纵向研究（China Health and Retirement Longitudinal Study）的四个时间点（2011 年、2013 年、2015 年和 2018 年）的数据。在基线时测量握力。握力不对称定义为非优势手与优势手的握力之比（即非优势手/优势手）：<0.9 定义为优势手握力不对称，>1.1 定义为非优势手握力不对称。握力弱定义为男性<28kg 或女性<18kg。
在每个时间点评估和标准化认知功能及其两个核心维度（情景记忆和精神状态）。
共纳入 9333 名参与者（48.3%为女性，年龄 58.2±9.0 岁）。非优势手但非优势手握力不对称与基线时认知功能较差显著相关（精神状态、情景记忆和总体认知的β值分别为-0.121、-0.092 和-0.132）。在 2 年的纵向分析中，优势手握力不对称显著减缓认知衰退（精神状态和总体认知的β值分别为-0.078 和-0.069），而非优势手握力不对称加速认知衰退（情景记忆和总体认知的β值分别为 0.053 和 0.043）。握力弱与基线时认知功能差和 2、4、7 年的认知衰退相关（均 P<0.05）。
在中老年人群中，非优势手握力不对称和握力弱与认知功能较差相关，并预测认知衰退加速。优势手握力不对称可能对维持认知功能有益。
