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公民身份状态对小儿肝肾移植机会的影响。

Effect of citizenship status on access to pediatric liver and kidney transplantation.

机构信息

Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, USA.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

出版信息

Am J Transplant. 2024 Oct;24(10):1868-1880. doi: 10.1016/j.ajt.2024.06.008. Epub 2024 Jun 20.

DOI:10.1016/j.ajt.2024.06.008
PMID:38908484
Abstract

Transplantation of non-US citizen residents remains controversial. We evaluate national trends in transplant activity among pediatric noncitizen residents (PNCR). Pediatric liver and kidney transplant data were obtained from the Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients. Data on transplanted organs, region, waitlist additions, procedures, and citizenship status were analyzed from 2012-2022. Rates of PNCR transplantation activity were compared with population rates from the US Census Bureau. On average, 713 ± 47 pediatric liver and 1039 ± 51 kidney patients were added to the waitlist, with 544 ± 32 liver and 742 ± 33 kidney transplants performed annually. Of these, PNCR comprised 1.5% and 3.3% of liver and kidney waitlist additions and 1.5% and 2.9% of liver and kidney transplant procedures, respectively. There were no significant changes in waitlist or transplant activity nationwide over the study period. There was a significant geographic variation in the percentage of waitlist additions and transplants across the United Network for Organ Sharing regions among the PNCR for liver and kidney transplantation. This is the first study to evaluate national trends in transplantation activity among PNCRs. The significant regional variation in transplantation activity for PNCR may suggest multilevel structural and systemic barriers to transplant accessibility.

摘要

非美国公民居民的移植仍然存在争议。我们评估了儿科非公民居民(PNCR)的移植活动的国家趋势。儿科肝和肾移植数据来自器官采购和移植网络以及移植受者科学登记处。分析了 2012 年至 2022 年期间移植器官、地区、候补名单增加、程序和公民身份的数据。PNCR 移植活动的比率与美国人口普查局的人口比率进行了比较。平均而言,每年有 713 ± 47 名儿科肝和 1039 ± 51 名儿科肾患者被添加到候补名单,每年进行 544 ± 32 例肝和 742 ± 33 例肾移植。其中,PNCR 分别占肝和肾候补名单增加和肝和肾移植程序的 1.5%和 3.3%。在研究期间,全国范围内的候补名单或移植活动没有明显变化。在 United Network for Organ Sharing 地区,PNCR 的肝和肾移植候补名单和移植的百分比在全国范围内存在显著的地域差异。这是第一项评估 PNCR 移植活动国家趋势的研究。PNCR 移植活动的显著区域差异可能表明移植可及性存在多层次的结构性和系统性障碍。

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