Service de Biochimie, Université de Paris Saclay, Hôpital Paul Brousse, AP-HP, Paris, France.
INSERM 1151, Université de Paris, École Pratique des Hautes Études/PSL Research University, Institut Necker Enfants Malades (INEM), Paris, France.
Trends Immunol. 2024 Jul;45(7):495-510. doi: 10.1016/j.it.2024.05.007. Epub 2024 Jun 21.
Over the past decade our research has implemented a multimodal approach to human lymphopoiesis, combining clonal-scale mapping of lymphoid developmental architecture with the monitoring of dynamic changes in the pattern of lymphocyte generation across ontogeny. We propose that lymphopoiesis stems from founder populations of CD127/interleukin (IL)7R or CD127/IL7R early lymphoid progenitors (ELPs) polarized respectively toward the T-natural killer (NK)/innate lymphoid cell (ILC) or B lineages, arising from newly characterized CD117 multi-lymphoid progenitors (MLPs). Recent data on the lifelong lymphocyte dynamics of healthy donors suggest that, after birth, lymphopoiesis may become increasingly oriented toward the production of B lymphocytes. Stemming from this, we posit that there are three major developmental transitions, the first occurring during the neonatal period, the next at puberty, and the last during aging.
在过去的十年中，我们的研究采用了多模式方法来研究人类淋巴发生，将淋巴样发育结构的克隆尺度作图与在个体发生过程中淋巴细胞生成模式的动态变化的监测相结合。我们提出，淋巴发生源自分别向 T 天然杀伤 (NK)/先天淋巴细胞 (ILC) 或 B 谱系极化的 CD127/白细胞介素 (IL)7R 或 CD127/IL7R 早期淋巴祖细胞 (ELP) 的创始人群体，这些群体起源于新描述的 CD117 多淋巴祖细胞 (MLP)。关于健康供体终生淋巴细胞动态的最新数据表明，出生后，淋巴发生可能越来越倾向于产生 B 淋巴细胞。基于此，我们假设存在三个主要的发育转变，第一个发生在新生儿期，第二个发生在青春期，第三个发生在衰老期。
