Department of Traditional Chinese Medicine & Integrated Traditional Chinese and Western Medicine, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
Department of Oncology Radiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
Nutr Cancer. 2024;76(9):824-830. doi: 10.1080/01635581.2024.2364392. Epub 2024 Jun 23.
Postoperative adjuvant chemotherapy could improve the life quality of patients with breast cancer but also bring side effects and cause adverse reactions. Yiqi Yangyin decoction has been reported to possess anti-cancer activity and has been employed in the postoperative treatment of various cancers. A total of 128 patients with breast cancer who received surgical therapy were enrolled in this study and were randomly grouped as the control and the test group to receive different therapies. Patients in the control group received single chemotherapy of fluorouracil and hydrochloride, while the therapy of the test group patients supplemented Yiqi Yangyin decoction based on the control group. Both two therapeutic strategies improved life quality and TCM syndrome scores of enrolled patients, and the supplement of Yiqi Yangyin decoction significantly improved the therapeutic effect. Adverse reactions including nausea, vomiting, thrombocytopenia, diarrhea, leukopenia, and hemoglobinia occurred in both two groups, but the application of Yiqi Yangyin decoction significantly alleviated adverse reactions. Additionally, patients in the test group showed a better 1-year disease-free survival. The combination of adjuvant chemotherapy with Yiqi Yangyin decoction could improve postoperative life quality, improve therapeutic efficacy, and reduce adverse reactions in patients with breast cancer.
术后辅助化疗可以提高乳腺癌患者的生活质量，但也会带来副作用并引起不良反应。已报道益气养阴汤具有抗癌活性，并已用于各种癌症的术后治疗。本研究共纳入 128 例接受手术治疗的乳腺癌患者，并随机分为对照组和试验组接受不同的治疗。对照组患者接受氟尿嘧啶和盐酸单药化疗，而试验组患者在对照组的基础上补充益气养阴汤。两种治疗策略均改善了入组患者的生活质量和中医证候评分，而益气养阴汤的补充显著提高了治疗效果。两组均出现恶心、呕吐、血小板减少、腹泻、白细胞减少和贫血等不良反应，但应用益气养阴汤可显著减轻不良反应。此外，试验组患者的 1 年无病生存率更好。辅助化疗联合益气养阴汤可提高乳腺癌患者术后生活质量，提高疗效，降低不良反应。
