Ling Jun, Yang Yan-Hua
Department of Pharmacy, Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou NO. 7 People's Hospital, Changzhou 213000, Jiangsu Province, China.
World J Diabetes. 2023 Sep 15;14(9):1412-1421. doi: 10.4239/wjd.v14.i9.1412.
Early diabetic nephropathy (DN) is a complication of diabetes mellitus. It mainly affects kidney microvessels and glomerular function, and its timely and effective treatment is critical for early DN. However, the effects of treatments comprising simple Western medicine are not optimal. With the promotion and implementation of integrated Chinese and western medicine treatments, remarkable results have been achieved for many diseases. To this end, we explored the clinical efficacy of integrated traditional Chinese and western medicines for the treatment of early DN.
To investigate the effect of sitagliptin tablets combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in patients with early DN.
Through a retrospective analysis, 123 patients with early DN were admitted to the endocrinology clinic of the Changzhou NO. 7 People's Hospital from January 2021 to October 2022 and were selected as study subjects. After rigorous screening, 100 patients with early DN were enrolled. The control group (CG, = 50) and the observation group (OG, = 50) were divided according to the treatment method. The CG were treated with sitagliptin, and the OG were treated with sitagliptin plus the Yiqi yangyin huoxue decoction. Both groups were treated for 3 mo. For both groups, the baseline data and clinical efficacy were compared, and changes in blood glucose levels, lipid levels, renal function, and hematological indicators before (T0) and after (T1) treatment were assessed.
The total effective rate for the OG was 94.00% and that of the CG was 80.00% ( < 0.05). After treatment (T1), the levels of fasting blood glucose, 2 h postprandial glucose, total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol in OG patients were obviously lower than those in the CG ( < 0.05), and cystatin C, homocysteine, urinary microalbumin, and blood creatinine values in OG patients were also obviously lower than those in the CG ( < 0.05); erythrocyte deposition, plasma viscosity, whole blood high shear viscosity, and whole blood low shear viscosity were markedly lower in OG patients than in the CG ( < 0.05).
Sitagliptin combined with Yiqi yangyin huoxue decoction has a remarkable effect when used to treat patients with early DN. Further, it is helpful in improving hemorheological indices and controlling disease progression.
早期糖尿病肾病（DN）是糖尿病的一种并发症。它主要影响肾脏微血管和肾小球功能，对早期DN进行及时有效的治疗至关重要。然而，单纯西药治疗的效果并不理想。随着中西医结合治疗的推广与实施，许多疾病都取得了显著疗效。为此，我们探讨了中西医结合治疗早期DN的临床疗效。
探讨西格列汀片联合益气养阴活血汤对早期DN患者临床疗效及血液流变学的影响。
通过回顾性分析，选取2021年1月至2022年10月在常州市第七人民医院内分泌科就诊的123例早期DN患者作为研究对象。经过严格筛选，纳入100例早期DN患者。根据治疗方法将患者分为对照组（CG，n = 50）和观察组（OG，n = 50）。对照组采用西格列汀治疗，观察组采用西格列汀加益气养阴活血汤治疗。两组均治疗3个月。比较两组的基线数据和临床疗效，并评估治疗前（T0）和治疗后（T1）血糖水平、血脂水平、肾功能和血液学指标的变化。
观察组总有效率为94.00%，对照组为80.00%（P < 0.05）。治疗后（T1），观察组患者的空腹血糖、餐后2小时血糖、总胆固醇、三酰甘油和低密度脂蛋白胆固醇水平明显低于对照组（P < 0.05），观察组患者的胱抑素C、同型半胱氨酸、尿微量白蛋白和血肌酐值也明显低于对照组（P < 0.05）；观察组患者的红细胞沉降率、血浆黏度、全血高切黏度和全血低切黏度明显低于对照组（P < 0.05）。
西格列汀联合益气养阴活血汤治疗早期DN患者疗效显著。此外，它有助于改善血液流变学指标并控制疾病进展。
