Gardner C R
Biomaterials. 1985 May;6(3):153-60. doi: 10.1016/0142-9612(85)90003-1.
Potential and limitations of current efforts in drug targeting are discussed in terms of the criterion that targeting strategies must ultimately be gauged by their success in producing selectivity of pharmacological response thereby reducing or eliminating side effects which are not mechanism-related. A wide variety of approaches are considered, including: local drug administration, differential metabolism, carriers and vehicles, macromolecular recognition, site-specific activation and molecular specificity. Each approach is briefly assessed for its potential to be developed as a realistic candidate for human health care.
根据靶向策略最终必须依据其在产生药理反应选择性方面的成功程度来衡量这一标准，讨论了当前药物靶向研究工作的潜力和局限性，从而减少或消除与机制无关的副作用。考虑了各种各样的方法，包括：局部给药、差异代谢、载体和运载体、大分子识别、位点特异性激活和分子特异性。对每种方法作为人类医疗保健实际候选方法的开发潜力进行了简要评估。
