Talja M
Br J Urol. 1985 Jun;57(3):329-33. doi: 10.1111/j.1464-410x.1985.tb06355.x.
Severe urethral inflammatory reactions followed by strictures have been reported after short-term catheterisation with latex catheters since 1982. In this study a new method for assessing tissue toxicity is presented. It is based on the degree of inhibition of rat peritoneal foreign body reaction. Because the results are easier to interpret and more quantitative than those of the rabbit muscle implantation test, the rat peritoneal implantation test is recommended as a standard in vivo toxicity test.
自1982年以来，有报道称使用乳胶导尿管进行短期导尿后会出现严重的尿道炎症反应并继发狭窄。本研究提出了一种评估组织毒性的新方法。该方法基于对大鼠腹膜异物反应的抑制程度。由于该结果比兔肌肉植入试验的结果更易于解释且更具定量性，因此推荐将大鼠腹膜植入试验作为一种标准的体内毒性试验。
