Ruutu M, Alfthan O, Talja M, Andersson L C
Br J Urol. 1985 Feb;57(1):82-7. doi: 10.1111/j.1464-410x.1985.tb08992.x.
After an epidemic of severe urethral strictures in cardiac surgery patients, all brand latex catheters marketed in Finland were investigated for cellular toxicity with eluates made from the catheters. Four of the seven brands, including the one involved in the stricture cases, showed marked cytotoxicity and inhibited almost all cell growth in various human cell cultures when a 30% catheter eluate was used. DNA histograms of cells cultured with toxic catheter eluate showed inhibition of DNA synthesis. Silicone catheters did not influence cell growth, which correlates with the finding that no new stricture cases were seen after the latex catheters were replaced with silicone ones. Attention is paid to the facts that international standards regarding urethral catheter toxicity are lacking and that catheter quality control is insufficient.
在心脏手术患者中出现严重尿道狭窄的疫情后，对芬兰市场上销售的所有品牌乳胶导管进行了调查，用导管洗脱液检测其细胞毒性。七个品牌中的四个，包括涉及狭窄病例的那个品牌，当使用30%的导管洗脱液时，在各种人类细胞培养物中显示出明显的细胞毒性，并几乎抑制了所有细胞生长。用有毒导管洗脱液培养的细胞的DNA直方图显示DNA合成受到抑制。硅胶导管不影响细胞生长，这与用硅胶导管取代乳胶导管后未出现新的狭窄病例的发现相关。人们关注到缺乏关于尿道导管毒性的国际标准以及导管质量控制不足的事实。
