Centre for Parasitology, School of Infection and Immunity, College of Medicine, Veterinary and Life Sciences, University of Glasgow, G12 8TA Glasgow, UK.
Centre for Parasitology, School of Infection and Immunity, College of Medicine, Veterinary and Life Sciences, University of Glasgow, G12 8TA Glasgow, UK.
Trends Parasitol. 2024 Jul;40(7):541-543. doi: 10.1016/j.pt.2024.06.004. Epub 2024 Jun 22.
Small-Saunders et al. uncovered a new facet of artemisinin resistance in Plasmodium in which parasites use a previously underexplored arm of stress response mechanisms. Through altered epitranscriptomic modifications on tRNA, changed translation patterns adapt resistant cells to facilitate entry into a quiescent-like state which provides the parasite an escape from many drugs.
Small-Saunders 等人揭示了青蒿素耐药性的一个新方面，即寄生虫利用以前未充分探索的应激反应机制的一个分支。通过改变 tRNA 的表观转录组修饰，改变的翻译模式使耐药细胞适应进入类似静止的状态，使寄生虫逃避许多药物。
