Botswana Harvard Health Partnership, Gaborone, Botswana.
Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Sci Rep. 2024 Jun 23;14(1):14432. doi: 10.1038/s41598-024-65099-w.
Chronic HIV disease is associated with a fivefold increase in albuminuria outside of sub-Saharan Africa. However, very little is known about albuminuria risk among people living with HIV (PLWH) in sub-Saharan Africa. Therefore, we conducted a cross-sectional observational HIV clinic-based study of albuminuria among 1533 adults aged 21 years or older between January 2020 and January 2021 in Gaborone, Botswana. Clinical albuminuria was defined using a sex-based albumin‒creatinine ratio (ACR) of 25-355 mg/g for females and 17-250 mg/g for males. The study population mean age was 48.5 (SD 10.3) years, and 764/1533 (49.7%) were female. The overall prevalence of albuminuria was 20.7% (95% CI 18.7%, 22.8%). A higher proportion of males were more likely to be categorized as having albuminuria than females, 25% (95% CI 22.0, 28.2) versus 16.4% (95% CI 13.8,19.2), P value < 0.001. In the final multivariate models, predictors of albuminuria differed by sex group. Larger longitudinal studies are required to evaluate the impact of albuminuria among PLWH with particular emphasis on the effect of sex on the risk of albuminuria.
慢性 HIV 疾病与撒哈拉以南非洲以外地区白蛋白尿的五倍增加相关。然而，对于撒哈拉以南非洲地区 HIV 感染者（PLWH）的白蛋白尿风险知之甚少。因此，我们对 2020 年 1 月至 2021 年 1 月期间在博茨瓦纳哈博罗内的 1533 名年龄在 21 岁及以上的成年人进行了一项基于 HIV 诊所的横断面观察性白蛋白尿研究。临床白蛋白尿使用基于性别的白蛋白-肌酐比（ACR）定义，女性为 25-355mg/g，男性为 17-250mg/g。研究人群的平均年龄为 48.5（SD 10.3）岁，764/1533（49.7%）为女性。白蛋白尿的总体患病率为 20.7%（95%CI 18.7%，22.8%）。与女性相比，更多的男性更有可能被归类为白蛋白尿，分别为 25%（95%CI 22.0，28.2）和 16.4%（95%CI 13.8，19.2），P 值<0.001。在最终的多变量模型中，白蛋白尿的预测因素因性别组而异。需要进行更大的纵向研究来评估 PLWH 中白蛋白尿的影响，特别是强调性别对白蛋白尿风险的影响。
