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本文引用的文献

1
T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women.T 细胞激活和衰老可预测 HIV 感染女性的亚临床颈动脉疾病。
J Infect Dis. 2011 Feb 15;203(4):452-63. doi: 10.1093/infdis/jiq071. Epub 2011 Jan 10.
2
Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients.估算肾小球滤过率、慢性肾脏病与 HIV 阳性患者的抗反转录病毒药物使用。
AIDS. 2010 Jul 17;24(11):1667-78. doi: 10.1097/QAD.0b013e328339fe53.
3
Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis.估算肾小球滤过率和白蛋白尿与普通人群全因和心血管死亡率的关系：荟萃分析协作研究。
Lancet. 2010 Jun 12;375(9731):2073-81. doi: 10.1016/S0140-6736(10)60674-5. Epub 2010 May 17.
4
Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons.肾功能和白蛋白尿与 HIV 感染者心血管事件的关系。
Circulation. 2010 Feb 9;121(5):651-8. doi: 10.1161/CIRCULATIONAHA.109.898585. Epub 2010 Jan 25.
5
Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis.基于人群研究中肱动脉血流介导的血管舒张功能对心血管事件发生的预测价值：动脉粥样硬化的多民族研究
Circulation. 2009 Aug 11;120(6):502-9. doi: 10.1161/CIRCULATIONAHA.109.864801. Epub 2009 Jul 27.
6
Proteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects.未接受抗逆转录病毒治疗的HIV感染者的蛋白尿、肌酐清除率及免疫激活情况。
J Infect Dis. 2009 Aug 15;200(4):614-8. doi: 10.1086/600890.
7
The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy era.在高效抗逆转录病毒治疗时代，1型人类免疫缺陷病毒（HIV-1）病毒抑制及非病毒因素对定量蛋白尿的影响。
Antivir Ther. 2009;14(4):543-9.
8
Relations of measures of endothelial function and kidney disease: the Framingham Heart Study.内皮功能指标与肾脏疾病的关系：弗雷明汉心脏研究
Am J Kidney Dis. 2008 Nov;52(5):859-67. doi: 10.1053/j.ajkd.2008.04.027. Epub 2008 Jul 9.
9
Proteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study.稳定期HIV感染患者的蛋白尿与内皮功能障碍：一项初步研究。
J Acquir Immune Defic Syndr. 2007 Aug 15;45(5):596-8. doi: 10.1097/QAI.0b013e318061d2fa.
10
Microalbuminuria in HIV infection.HIV感染中的微量白蛋白尿
AIDS. 2007 May 11;21(8):1003-9. doi: 10.1097/QAD.0b013e3280d3587f.

在没有糖尿病或高血压的 HIV 感染患者中，蛋白尿和白蛋白尿均与内皮功能障碍无关。

Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.

机构信息

Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

出版信息

J Infect Dis. 2011 Dec 15;204(12):1946-50. doi: 10.1093/infdis/jir668. Epub 2011 Oct 19.

DOI:10.1093/infdis/jir668
PMID:22013226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3209818/
Abstract

It is unknown whether systemic endothelial dysfunction underlies the association between nephropathy and cardiovascular disease (CVD) in persons infected with human immunodeficiency virus (HIV). Spot urine protein to creatinine ratio, spot urine albumin to creatinine ratio, creatinine clearance, estimated glomerular filtration rate, and flow-mediated dilation (FMD) of the brachial artery were evaluated in 123 study participants infected with HIV (58 receiving antiretroviral therapy [ART] and 65 not receiving ART) with no history of diabetes or hypertension. None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV.

摘要

目前尚不清楚在感染人类免疫缺陷病毒 (HIV) 的人群中，肾病和心血管疾病 (CVD) 之间的关联是否源于全身内皮功能障碍。本研究评估了 123 名无糖尿病或高血压病史的 HIV 感染者（58 名接受抗逆转录病毒治疗 [ART]，65 名未接受 ART）的尿蛋白/肌酐比值、尿白蛋白/肌酐比值、肌酐清除率、估计肾小球滤过率和肱动脉血流介导的舒张功能（FMD）。肾功能标志物均未与 FMD 相关，无论是连续变量还是分类变量。与预期相反，内皮功能障碍可能不是 HIV 患者中肾病和 CVD 之间的联系。