Expression of H-2 antigen on oligodendrocytes is induced by soluble factors from concanavalin A activated T cells.

It has been shown that soluble factors from activated T cells, or interferon alone, enhance the expression of major histocompatibility complex (MHC) antigens in several cell types. In this study we have demonstrated, by means of indirect immunofluorescence and radioimmunoassay, that the expression of mouse MHC class I antigen (H-2) on isolated mouse oligodendrocytes is induced by soluble factors from concanavalin A activated T cells. Autoradiographic studies indicate that this induction of H-2 expression is not accompanied by proliferation of oligodendrocytes.