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Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.干扰素-γ和肿瘤坏死因子对人多形核中性粒细胞功能的激活作用。
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肿瘤坏死因子可诱导小鼠星形胶质细胞上主要组织相容性复合体I类抗原的表达。

Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes.

作者信息

Lavi E, Suzumura A, Murasko D M, Murray E M, Silberberg D H, Weiss S R

机构信息

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104.

出版信息

J Neuroimmunol. 1988 Jun;18(3):245-53. doi: 10.1016/0165-5728(88)90102-6.

DOI:10.1016/0165-5728(88)90102-6
PMID:2452831
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7120086/
Abstract

The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions.

摘要

在体外培养的小鼠神经胶质细胞中，研究了肿瘤坏死因子（TNF）对主要组织相容性复合体（MHC）抗原表达的影响。TNF诱导星形胶质细胞表面表达MHC I类抗原，但不诱导MHC II类抗原表达，且少突胶质细胞表面无此现象。神经胶质细胞通常不表达可检测量的MHC抗原。因此，TNF可能在涉及MHC I类限制性反应的神经疾病免疫发病机制中发挥作用。