Zhao Qing-Qing, Shu Xian-Long, Yuan Zhen, Gao Qian, Huang Ying, Yang Yuan-Qing, Peng Li-Ming, Wang Guo, Chen Xiao-Ping, Chen Bi-Lian, Tang Jie
Department of Clinical Pharmacology, Xiangya Hospital; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
Biol Trace Elem Res. 2025 Feb;203(2):754-765. doi: 10.1007/s12011-024-04227-z. Epub 2024 Jun 24.
Humans are exposed to various chemical elements that have been associated with the development and progression of diseases such as coronary artery disease (CAD). Unlike previous research, we employed a multi-element approach to investigate CAD patients and those with comorbid conditions such as diabetes (CAD-DM2), high blood pressure (CAD-HBP), or high blood lipids (CAD-HBL). Plasma concentrations of 21 elements, including lithium (Li), boron (B), aluminum (Al), calcium (Ca), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), strontium (Sr), cadmium (Cd), tin (Sn), stibium (Sb), barium (Ba), and lead (Pb), were measured in CAD patients (n = 201) and healthy subjects (n = 110) using inductively coupled plasma-mass spectrometry (ICP-MS). Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models were utilized to analyze the ionomic profiles. Spearman correlation analysis was employed to identify the interaction patterns among individual elements. We found that levels of Ba, Li, Ni, Zn and Pb were elevated in the CAD group compared to the healthy group, while Sb, Ca, Cu, Ti, Fe, and Se were lower. Furthermore, the CAD-DM2 group exhibited higher levels of Ni and Cd, while the CAD-HBP group showed lower levels of Co and Mn. In the CAD-HBL group, Ti was increased, whereas Ba, Cr, Cu, Co, Mn, and Ni were reduced. In conclusion, ionomic profiles can be utilized to differentiate CAD patients from healthy individuals, potentially providing insights for future treatment or dietary interventions.
人类会接触到各种与冠状动脉疾病（CAD）等疾病的发生和发展相关的化学元素。与以往的研究不同，我们采用多元素方法来研究CAD患者以及患有糖尿病（CAD-DM2）、高血压（CAD-HBP）或高血脂（CAD-HBL）等合并症的患者。使用电感耦合等离子体质谱法（ICP-MS）测量了CAD患者（n = 201）和健康受试者（n = 110）血浆中21种元素的浓度，包括锂（Li）、硼（B）、铝（Al）、钙（Ca）、钛（Ti）、钒（V）、铬（Cr）、锰（Mn）、铁（Fe）、钴（Co）、镍（Ni）、铜（Cu）、锌（Zn）、砷（As）、硒（Se）、锶（Sr）、镉（Cd）、锡（Sn）、锑（Sb）、钡（Ba）和铅（Pb）。利用主成分分析（PCA）和正交偏最小二乘判别分析（OPLS-DA）模型分析离子组学图谱。采用Spearman相关分析来确定各元素之间的相互作用模式。我们发现，与健康组相比，CAD组中Ba、Li、Ni、Zn和Pb的水平升高，而Sb、Ca、Cu、Ti、Fe和Se的水平降低。此外，CAD-DM2组中Ni和Cd的水平较高，而CAD-HBP组中Co和Mn的水平较低。在CAD-HBL组中，Ti增加，而Ba、Cr、Cu、Co、Mn和Ni减少。总之，离子组学图谱可用于区分CAD患者和健康个体，可能为未来的治疗或饮食干预提供见解。
