Chughtai Muhammad Aamir, Kerimkulova Munara K, Mushtaq Omid, Hagenahalli Anand Vibhavari, Rehman Abdur, Shehryar Abdullah, Hassan Baran, Islam Rabia, Islam Hamza, Mansoor Muzafar, Rehman Shehryar
Internal Medicine, Punjab Medical College, Faisalabad, PAK.
Internal Medicine, Kyrgyz State Medical Academy, Bishkek, KGZ.
Cureus. 2024 May 23;16(5):e60962. doi: 10.7759/cureus.60962. eCollection 2024 May.
Gastrointestinal (GI) disorders, including gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), gastritis/peptic ulcer disease (PUD), and celiac disease, significantly impact global health and economic stability. This review synthesizes current literature to elucidate the pathophysiology, clinical manifestations, diagnostic challenges, and management strategies of these prevalent conditions. Through a biopsychosocial lens, we examine the role of the gut microbiome in disease modulation and explore innovative therapeutic advancements, including microbiome-targeting interventions. The review highlights the necessity of a multidisciplinary approach to patient care, integrating medical treatment with dietary, psychological, and lifestyle modifications. By addressing these disorders holistically, the article aims to foster a deeper understanding of their biopsychosocial impacts and encourage more effective, patient-centered treatment paradigms. The findings underscore the imperative for continued research and interdisciplinary collaboration to enhance patient outcomes and reduce healthcare burdens associated with GI disorders.
胃肠道疾病，包括胃食管反流病（GERD）、炎症性肠病（IBD）、胃炎/消化性溃疡病（PUD）和乳糜泻，对全球健康和经济稳定产生重大影响。本综述综合了当前文献，以阐明这些常见疾病的病理生理学、临床表现、诊断挑战和管理策略。通过生物心理社会视角，我们研究了肠道微生物群在疾病调节中的作用，并探索了创新的治疗进展，包括针对微生物群的干预措施。该综述强调了多学科方法在患者护理中的必要性，将药物治疗与饮食、心理和生活方式的改变相结合。通过全面解决这些疾病，本文旨在促进对其生物心理社会影响的更深入理解，并鼓励采用更有效、以患者为中心的治疗模式。研究结果强调了持续研究和跨学科合作的必要性，以改善患者预后并减轻与胃肠道疾病相关的医疗负担。
