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2
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Relative etiological role of prior hepatitis B virus infection and nonalcoholic fatty liver disease in the development of non-B non-C hepatocellular carcinoma in a hepatitis B-endemic area.在乙型肝炎高发地区，既往乙型肝炎病毒感染和非酒精性脂肪性肝病在非乙型肝炎非丙型肝炎相关性肝细胞癌发展中的相对病因学作用。
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Elevated serum soluble CD14 levels in chronic HBV infection are significantly associated with HBV-related hepatocellular carcinoma.慢性乙肝病毒感染中血清可溶性CD14水平升高与乙肝病毒相关肝细胞癌显著相关。
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PRDM1 levels are associated with clinical diseases in chronic HBV infection and survival of patients with HBV-related hepatocellular carcinoma.PRDM1 水平与慢性 HBV 感染中的临床疾病及 HBV 相关肝细胞癌患者的生存相关。
Int Immunopharmacol. 2019 Aug;73:156-162. doi: 10.1016/j.intimp.2019.05.012. Epub 2019 May 14.
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Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis.大量饮酒会增加乙型肝炎病毒相关肝硬化患者肝细胞癌的发病率。
J Hepatol. 2013 Apr;58(4):730-5. doi: 10.1016/j.jhep.2012.11.045. Epub 2012 Dec 6.
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Clinical Value Evaluation of microRNA-324-3p and Other Available Biomarkers in Patients With HBV Infection-Related Hepatocellular Carcinoma.微小RNA-324-3p及其他可用生物标志物在乙型肝炎病毒感染相关肝细胞癌患者中的临床价值评估
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Association of Heavy Alcohol Intake and ALDH2 rs671 Polymorphism With Hepatocellular Carcinoma and Mortality in Patients With Hepatitis B Virus-Related Cirrhosis.大量饮酒与 ALDH2 rs671 多态性与乙型肝炎病毒相关肝硬化患者肝细胞癌及死亡率的关系。
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Serum secreted frizzled-related protein 5 levels differentially decrease in patients with hepatitis B virus-associated chronic infection and hepatocellular carcinoma.在乙型肝炎病毒相关慢性感染和肝细胞癌患者中，血清分泌型卷曲相关蛋白5水平呈不同程度下降。
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The necroptosis related gene LGALS3 can be used as a biomarker for the adverse progression from chronic HBV infection to HCC.LGALS3 基因的坏死相关基因可作为慢性 HBV 感染向 HCC 不良进展的生物标志物。
Front Immunol. 2023 Apr 26;14:1142319. doi: 10.3389/fimmu.2023.1142319. eCollection 2023.

本文引用的文献

1
Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus- and Hepatitis C Virus-Related Hepatocellular Carcinoma.抗病毒治疗在乙型肝炎病毒和丙型肝炎病毒相关肝细胞癌切除术后的应用及 10 年结果。
J Clin Oncol. 2024 Mar 1;42(7):790-799. doi: 10.1200/JCO.23.00757. Epub 2024 Jan 4.
2
Utilization of Antiviral Therapy for Patients With Hepatitis B-Related Hepatocellular Carcinoma: A Nationwide Real-World US Study.抗病毒治疗在乙型肝炎相关肝细胞癌患者中的应用：一项全国性真实世界美国研究。
Clin Gastroenterol Hepatol. 2023 Dec;21(13):3305-3313.e4. doi: 10.1016/j.cgh.2023.04.020. Epub 2023 Apr 30.
3
Hepatocellular carcinoma surveillance - utilization, barriers and the impact of changing aetiology.肝细胞癌监测——利用、障碍以及病因变化的影响。
Nat Rev Gastroenterol Hepatol. 2023 Dec;20(12):797-809. doi: 10.1038/s41575-023-00818-8. Epub 2023 Aug 3.
4
Clinical Distribution Characteristics and Identification for Significant Liver Inflammation of Patients in Chronic Hepatitis B with Indeterminate Phase.慢性乙型肝炎不确定期患者显著肝炎症的临床分布特征及识别
Gastroenterol Res Pract. 2023 Jul 11;2023:7264601. doi: 10.1155/2023/7264601. eCollection 2023.
5
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.美国肝病研究学会肝细胞癌预防、诊断和治疗实践指南。
Hepatology. 2023 Dec 1;78(6):1922-1965. doi: 10.1097/HEP.0000000000000466. Epub 2023 May 22.
6
Antiviral therapy substantially reduces HCC risk in patients with chronic hepatitis B infection in the indeterminate phase.抗病毒治疗可大幅降低处于不确定阶段的慢性乙型肝炎感染患者患肝癌的风险。
Hepatology. 2023 Nov 1;78(5):1558-1568. doi: 10.1097/HEP.0000000000000459. Epub 2023 May 16.
7
Global burden of hepatitis B virus: current status, missed opportunities and a call for action.全球乙型肝炎病毒负担：现状、错失的机会和行动呼吁。
Nat Rev Gastroenterol Hepatol. 2023 Aug;20(8):524-537. doi: 10.1038/s41575-023-00760-9. Epub 2023 Apr 6.
8
Utility of combining PIVKA-II and AFP in the surveillance and monitoring of hepatocellular carcinoma in the Asia-Pacific region.联合检测 PIVKA-II 和 AFP 在亚太地区肝细胞癌监测和随访中的应用。
Clin Mol Hepatol. 2023 Apr;29(2):277-292. doi: 10.3350/cmh.2022.0212. Epub 2023 Jan 30.
9
HBcrAg Predicts Hepatocellular Carcinoma Development in Chronic B Hepatitis Related Liver Cirrhosis Patients Undergoing Long-Term Effective Anti-Viral.HBcrAg 预测长期有效抗病毒治疗的慢性乙型肝炎相关肝硬化患者发生肝细胞癌。
Viruses. 2022 Nov 29;14(12):2671. doi: 10.3390/v14122671.
10
Significant histological disease of patients with chronic hepatitis B virus infection in the grey zone.慢性乙型肝炎病毒感染患者灰区中显著的组织学疾病。
Aliment Pharmacol Ther. 2023 Mar;57(5):464-474. doi: 10.1111/apt.17272. Epub 2022 Nov 2.

Optimizing care of HBV infection and HBV-related HCC.

作者信息

Lee Shi Yan, Nah Benjamin Kai Yi, Leo Jazleen, Koh Jia Hong, Huang Daniel Q

机构信息

Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore, Singapore.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

出版信息

Clin Liver Dis (Hoboken). 2024 Jun 21;23(1):e0169. doi: 10.1097/CLD.0000000000000169. eCollection 2024 Jan-Jun.

DOI:10.1097/CLD.0000000000000169
PMID:38911998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11192014/
Abstract
摘要