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Numerous biomedically important cargoes depend on adaptor protein complex-1 (AP-1) for their localization. However, controversy surrounds whether AP-1 mediates traffic from or to the Golgi. Robinson et al. (https://www.doi.org/10.1083/jcb.202310071) present compelling evidence that AP-1 mediates recycling to the Golgi.

许多具有重要生物医学意义的货物依赖衔接蛋白复合物 1（AP-1）进行定位。然而，关于 AP-1 是否介导从高尔基体到或向高尔基体的运输一直存在争议。Robinson 等人（https://www.doi.org/10.1083/jcb.202310071）提出了令人信服的证据，表明 AP-1 介导了到高尔基体的再循环。