Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Acta Otolaryngol. 2024 Apr;144(4):272-276. doi: 10.1080/00016489.2024.2363462. Epub 2024 Jun 24.
Although various medical remedies have been attempted to alleviate the symptoms of Meniere's disease (MD), the risk-benefit ratios of these various treatments remain debatable.
We investigated the efficacy of sound stimulation of 100 Hz for treating vestibular dysfunction in patients with Meniere's disease (MD).
Patients with definitive MD with intractable vestibular symptoms and endolymphatic hydrops (EH) in the inner ear were evaluated. The experimental group received sound stimulation of 75 dB at a frequency of 100 Hz for 5 min, and the control group received sound stimulation of 75 dB at a frequency of 250 Hz for 5 min. Cervical vestibular-evoked myogenic potentials (cVEMPs) were measured before and after each sound stimulation, and the results of the clinical tests were compared between the two patient groups.
Significant increases in cVEMP amplitudes were observed after sound stimulation of 100 Hz in ears with vestibular endolymphatic hydrops, although no such improvement was observed in the control group.
Sound stimulation of 75 dB at a frequency of 100 Hz leads to improvement in cVEMP amplitude in patients with definitive MD. Adequate sound stimulation might be a new method for treating vestibular dysfunction associated with MD.
尽管已经尝试了各种医疗方法来缓解梅尼埃病（MD）的症状，但这些治疗方法的风险效益比仍存在争议。
我们研究了 100Hz 声音刺激治疗梅尼埃病（MD）患者前庭功能障碍的疗效。
评估了具有明确 MD 且伴有内耳内淋巴积水（EH）的难治性前庭症状的患者。实验组接受 75dB 频率为 100Hz 的声音刺激 5 分钟，对照组接受 75dB 频率为 250Hz 的声音刺激 5 分钟。在每次声音刺激前后测量颈性前庭诱发肌源性电位（cVEMP），并比较两组患者的临床测试结果。
在伴有前庭内淋巴积水的耳朵中，100Hz 声音刺激后 cVEMP 振幅显著增加，而对照组则没有观察到这种改善。
75dB 频率为 100Hz 的声音刺激可改善明确 MD 患者的 cVEMP 振幅。适当的声音刺激可能是治疗 MD 相关前庭功能障碍的一种新方法。
