Gu Yishuo, Ohgami Nobutaka, He Tingchao, Kagawa Takumi, Kurniasari Fitri, Tong Keming, Li Xiang, Tazaki Akira, Takeda Kodai, Mouri Masahiro, Kato Masashi
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine.
Activities of the Institute of Innovation for Future Society of Nagoya University.
Environ Health Prev Med. 2025;30:22. doi: 10.1265/ehpm.24-00247.
Motion sickness is a common transportation issue worldwide. Vestibular dysfunction has been reported to be a key etiology of motion sickness. However, there are limited technologies for alleviating motion sickness.
The most appropriate frequency (Hz) and level (dBZ) of pure tone for modulation of vestibular function were determined by an ex vivo study using murine utricle explants. The preventive effects of the selected pure tone on motion sickness were then confirmed by using a beam balance test in mice. The alleviating effects of pure tone on motion sickness induced by a swing, driving simulator or real car were objectively assessed by using posturography and electrocardiography (ECG) and were subjectively assessed by using the Motion Sickness Assessment Questionnaire (MSAQ) in humans.
The effect of short-term (≤5 min) exposure to a pure tone of 80-85 dBZ (= 60.9-65.9 dBA) at 100 Hz on motion sickness was investigated in mice and humans. A mouse study showed a long-lasting (≥120 min) alleviative effect on shaking-mediated exacerbated beam test scores by 5-min exposure to a pure tone of 85 dBZ at 100 Hz, which was ex vivo determined as a sound activating vestibular function, before shaking. Human studies further showed that 1-min exposure to a pure tone of 80-85 dBZ (= 60.9-65.9 dBA) at 100 Hz before shaking improved the increased envelope areas in posturography caused by the shakings of a swing, a driving simulator and a vehicle. Driving simulator-mediated activation of sympathetic nerves assessed by the heart rate variable (HRV) and vehicle-mediated increased scores of the MSAQ were improved by pure tone exposure before the shaking.
Since the exacerbated results of posturography and HRV reflect shaking-mediated imbalance and autonomic dysfunction, respectively, the results suggest that the imbalance and autonomic dysregulation in motion sickness could be improved by just 1-min exposure to a pure tone with daily exposable sound pressure levels.
Registration number: UMIN000022413 (2016/05/23-2023/04/19) and UMIN000053735 (2024/02/29-present).
晕动病是全球常见的交通相关问题。据报道，前庭功能障碍是晕动病的关键病因。然而，缓解晕动病的技术有限。
通过使用小鼠椭圆囊外植体的离体研究确定调节前庭功能的最合适纯音频率（Hz）和强度（dBZ）。然后通过小鼠的光束平衡试验确认所选纯音对晕动病的预防作用。通过姿势描记法和心电图（ECG）客观评估纯音对秋千、驾驶模拟器或真实汽车引起的晕动病的缓解作用，并通过晕动病评估问卷（MSAQ）在人体中进行主观评估。
在小鼠和人体中研究了在100 Hz下短期（≤5分钟）暴露于80 - 85 dBZ（= 60.9 - 65.9 dBA）的纯音对晕动病的影响。一项小鼠研究表明，在摇晃前5分钟暴露于100 Hz、85 dBZ的纯音对摇晃介导的加剧光束试验评分有持久（≥120分钟）的缓解作用，离体研究确定该声音可激活前庭功能。人体研究进一步表明，在摇晃前1分钟暴露于100 Hz、80 - 85 dBZ（= 60.9 - 65.9 dBA）的纯音可改善秋千、驾驶模拟器和车辆摇晃引起的姿势描记图中增加的包络面积。通过心率变异性（HRV）评估的驾驶模拟器介导的交感神经激活以及车辆介导的MSAQ评分增加在摇晃前通过纯音暴露得到改善。
由于姿势描记法和HRV的加剧结果分别反映了摇晃介导的失衡和自主神经功能障碍，结果表明，每天暴露于可承受声压水平的纯音仅1分钟即可改善晕动病中的失衡和自主神经调节异常。
注册号：UMIN000022413（2016/05/23 - 2023/04/19）和UMIN000053735（2024/02/29至今）。
