Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, Shandong, China.
Department of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao , Shandong, 266003, China.
Reprod Biol Endocrinol. 2024 Jun 24;22(1):73. doi: 10.1186/s12958-024-01247-1.
Preeclampsia is a multisystem progressive condition and is one of the most serious complications of pregnancy. Owing to its unclear pathogenesis, there are no precise and effective therapeutic targets for preeclampsia, and the only available treatment strategy is to terminate the pregnancy and eliminate the clinical symptoms. In recent years, non-coding RNAs have become a hotspot in preeclampsia research and have shown promise as effective biomarkers for the early diagnosis of preeclampsia over conventional biochemical markers. PIWI-interacting RNAs, novel small non-coding RNA that interact with PIWI proteins, are involved in the pathogenesis of various diseases at the transcriptional or post-transcriptional level. However, the mechanisms underlying the role of PIWI-interacting RNAs in the pathogenesis of preeclampsia remain unclear. In this review, we discuss the findings of existing studies on PIWI-interacting RNA biogenesis, functions, and their possible roles in preeclampsia, providing novel insights into the potential application of PIWI-interacting RNAs in the early diagnosis and clinical treatment of preeclampsia.
子痫前期是一种多系统进行性疾病，是妊娠最严重的并发症之一。由于其发病机制尚不清楚，目前对子痫前期尚无精确有效的治疗靶点，唯一可行的治疗策略是终止妊娠并消除临床症状。近年来，非编码 RNA 已成为子痫前期研究的热点，作为传统生化标志物的子痫前期早期诊断的有效生物标志物具有广阔的应用前景。PIWI 相互作用 RNA 是一种新型的小非编码 RNA，可与 PIWI 蛋白相互作用，在转录或转录后水平参与各种疾病的发病机制。然而，PIWI 相互作用 RNA 在子痫前期发病机制中的作用机制尚不清楚。在这篇综述中，我们讨论了现有的关于 PIWI 相互作用 RNA 的生物发生、功能及其在子痫前期中可能作用的研究结果，为 PIWI 相互作用 RNA 在子痫前期的早期诊断和临床治疗中的潜在应用提供了新的见解。
