Berezovskaia L N, Koroleva V G, Granatova E K, Grakovskaia L K
Antibiotiki. 1979 Nov;24(11):821-4.
Soviet doxycycline capsules in a dose of 0.1 g were studied in vitro (for disintegration and solubility) and in vivo (pharmacokinetics on 25 patients). It was found that Soviet doxycycline capsules provided comparatively rapid absorption of doxycycline. The antibiotic availability may be characterized by the solubility test. The results of the study on bioavailability of Soviet doxycycline capsules were compared with the results of analogous studies published by American authors for doxycycline capsules manufactured by various firms of the USA.
对剂量为0.1克的苏联强力霉素胶囊进行了体外（崩解和溶解度）和体内（25名患者的药代动力学）研究。发现苏联强力霉素胶囊能使强力霉素吸收相对较快。抗生素的可利用性可用溶解度试验来表征。将苏联强力霉素胶囊生物利用度的研究结果与美国作者发表的关于美国各公司生产的强力霉素胶囊类似研究结果进行了比较。
