Batuashvili T A, Shchedrin V I, Zak A F
Antibiotiki. 1979 Aug;24(8):611-5.
Bioavailability of experimental tablets and capsules of oxacillin was studied. Significant differences in absorption of the antibiotic from the above dosage forms were found. By the amount of the antibiotic absorbed the capsules were 3 times more effective than the tablets containing the same amount of oxacillin. The therapeutic concentrations of oxacillin in the blood after the use of the capsules persisted by an hour longer than after the use of the tablets. The results of the study on oxacillin absorption in rabbits allowed a prediction of the antibiotic absorption levels in humans.
对苯唑西林实验片剂和胶囊的生物利用度进行了研究。发现从上述剂型中吸收抗生素存在显著差异。就抗生素吸收量而言，胶囊的效果比含有相同量苯唑西林的片剂高3倍。使用胶囊后血液中苯唑西林的治疗浓度比使用片剂后持续时间长1小时。对家兔苯唑西林吸收的研究结果有助于预测人体对抗生素的吸收水平。
