Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran 1684613114, Iran.
Australasian Nanoscience and Nanotechnology Initiative (ANNI), Monash University LPO, Clayton, VIC 3168, Australia.
Curr Drug Targets. 2024;25(10):649-669. doi: 10.2174/0113894501294136240610061328.
Breast cancer is a pervasive global health issue that disproportionately impacts the female population. Over the past few years, there has been considerable interest in nanotechnology due to its potential utility in creating drug-delivery systems designed to combat this illness. The primary aim of these devices is to enhance the delivery of targeted medications, optimise the specific cells that receive the drugs, tackle treatment resistance in malignant cells, and introduce novel strategies for preventing and controlling diseases. This research aims to examine the methodologies utilised by various carrier nanoparticles in the context of therapeutic interventions for breast cancer. The main objective is to investigate the potential application of novel delivery technologies to attain timely and efficient diagnosis and treatment. Current cancer research predominantly examines diverse drug delivery methodologies for chemotherapeutic agents. These methodologies encompass the development of hydrogels, micelles, exosomes, and similar compounds. This research aims to analyse the attributes, intricacies, notable advancements, and practical applications of the system in clinical settings. Despite the demonstrated efficacy of these methodologies, an apparent discrepancy can be observed between the progress made in developing innovative therapeutic approaches and their widespread implementation in clinical settings. It is critical to establish a robust correlation between these two variables to enhance the effectiveness of medication delivery systems based on nanotechnology in the context of breast cancer treatment.
乳腺癌是一个全球性的健康问题,它对女性人口的影响不成比例。在过去的几年中,由于纳米技术在创建旨在治疗这种疾病的药物输送系统方面的潜在应用,人们对其产生了浓厚的兴趣。这些设备的主要目的是增强靶向药物的输送,优化接收药物的特定细胞,解决恶性细胞中的治疗抵抗问题,并引入预防和控制疾病的新策略。这项研究旨在检查各种载体纳米粒子在乳腺癌治疗干预中的应用方法。主要目标是研究新型递药技术的潜在应用,以实现及时有效的诊断和治疗。目前的癌症研究主要研究了各种化疗药物的不同药物输送方法。这些方法包括水凝胶、胶束、外泌体和类似化合物的开发。本研究旨在分析该系统在临床环境中的特性、复杂性、显著进展和实际应用。尽管这些方法已被证明具有疗效,但在开发创新治疗方法方面取得的进展与在临床环境中的广泛应用之间显然存在差异。建立这两个变量之间的强大相关性对于提高基于纳米技术的药物输送系统在乳腺癌治疗中的有效性至关重要。