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基于脂质体的纳米药物递送系统用于乳腺癌治疗:最新进展。

Liposomal Nano-Based Drug Delivery Systems for Breast Cancer Therapy: Recent Advances and Progresses.

机构信息

Department of Nanotechnology, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, 1684613114, Iran.

Australasian Nanoscience and Nanotechnology Initiative (ANNI), Monash University LPO, Clayton, VIC 3168, Australia.

出版信息

Anticancer Agents Med Chem. 2024;24(12):896-915. doi: 10.2174/0118715206293653240322041047.

Abstract

Breast cancer is a highly prevalent disease on a global scale, with a 30% incidence rate among women and a 14% mortality rate. Developing countries bear a disproportionate share of the disease burden, while countries with greater technological advancements exhibit a higher incidence. A mere 7% of women under the age of 40 are diagnosed with breast cancer, and the prevalence of this ailment is significantly diminished among those aged 35 and younger. Chemotherapy, radiation therapy, and surgical intervention comprise the treatment protocol. However, the ongoing quest for a definitive cure for breast cancer continues. The propensity for cancer stem cells to metastasize and resistance to treatment constitute their Achilles' heel. The advancement of drug delivery techniques that target cancer cells specifically holds significant promise in terms of facilitating timely detection and effective intervention. Novel approaches to pharmaceutical delivery, including nanostructures and liposomes, may bring about substantial changes in the way breast cancer is managed. These systems offer a multitude of advantages, such as heightened bioavailability, enhanced solubility, targeted tumor destruction, and diminished adverse effects. The application of nano-drug delivery systems to administer anti-breast cancer medications is a significant subject of research. This article delves into the domain of breast cancer, conventional treatment methods, the incorporation of nanotechnology into managerial tactics, and strategic approaches aimed at tackling the disease at its core.

摘要

乳腺癌是一种在全球范围内高发的疾病,女性发病率为 30%,死亡率为 14%。发展中国家承担着不成比例的疾病负担,而技术先进的国家发病率更高。仅有 7%的 40 岁以下女性被诊断患有乳腺癌,35 岁及以下女性的发病率显著降低。化疗、放疗和手术干预是治疗方案。然而,寻求乳腺癌根治方法的努力仍在继续。癌症干细胞转移和治疗耐药性是它们的致命弱点。针对癌细胞的药物输送技术的进步在及时发现和有效干预方面具有很大的潜力。新型药物输送方法,包括纳米结构和脂质体,可能会在乳腺癌的管理方式上带来重大变化。这些系统具有提高生物利用度、增强溶解度、靶向肿瘤破坏和减少不良反应等多种优势。纳米药物输送系统在给予抗乳腺癌药物方面的应用是一个重要的研究领域。本文深入探讨了乳腺癌领域、常规治疗方法、将纳米技术纳入管理策略以及针对疾病核心的战略方法。

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