Zhang Yifei, Huang Yixian, Li Song
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, USA.
AAPS PharmSciTech. 2014 Aug;15(4):862-71. doi: 10.1208/s12249-014-0113-z. Epub 2014 Apr 4.
Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. With small size (10-100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit prolonged circulation time in the blood and enhanced tumor accumulation. In this review, the importance of rational design was highlighted by summarizing the recent progress on the development of micellar formulations. Emphasis is placed on the new strategies to enhance the drug/carrier interaction for improved drug-loading capacity. In addition, the micelle-forming drug-polymer conjugates are also discussed which have both drug-loading function and antitumor activity.
聚合物胶束是一种用于难溶性抗癌药物的有效递送系统。聚合物胶束尺寸小（10 - 100纳米）且具有聚乙二醇（PEG）亲水性外壳，在血液中循环时间延长，肿瘤蓄积增强。在本综述中，通过总结胶束制剂开发的最新进展，强调了合理设计的重要性。重点介绍了增强药物/载体相互作用以提高载药能力的新策略。此外，还讨论了兼具载药功能和抗肿瘤活性的胶束形成型药物 - 聚合物缀合物。
