Geriatric Research, Education, and Clinical Center, Puget Sound VA Medical Center, VA Puget Sound Healthcare System, 1660 S Columbian Way, Seattle, WA, 98108, USA.
Healthcare Genetics Program, School of Nursing, Clemson University, Clemson, SC, USA.
BMC Geriatr. 2022 Aug 13;22(1):667. doi: 10.1186/s12877-022-03337-4.
Healthy aging relies on mitochondrial functioning because this organelle provides energy and diminishes oxidative stress. Single nucleotide polymorphisms (SNPs) in TOMM40, a critical gene that produces the outer membrane protein TOM40 of mitochondria, have been associated with mitochondrial dysfunction and neurodegenerative processes. Yet it is not clear whether or how the mitochondria may impact human longevity. We conducted this review to ascertain which SNPs have been associated with markers of healthy aging.
Using the PRISMA methodology, we conducted a systematic review on PubMed and Embase databases to identify associations between TOMM40 SNPs and measures of longevity and healthy aging.
Twenty-four articles were selected. The TOMM40 SNPs rs2075650 and rs10524523 were the two most commonly identified and studied SNPs associated with longevity. The outcomes associated with the TOMM40 SNPs were changes in BMI, brain integrity, cognitive functions, altered inflammatory network, vulnerability to vascular risk factors, and longevity.
Our systematic review identified multiple TOMM40 SNPs potentially associated with healthy aging. Additional research can help to understand mechanisms in aging, including resilience, prevention of disease, and adaptation to the environment.
健康老龄化依赖于线粒体功能，因为这个细胞器提供能量并减轻氧化应激。单核苷酸多态性（SNP）在 TOMM40 中，这是一个产生线粒体外膜蛋白 TOM40 的关键基因，与线粒体功能障碍和神经退行性过程有关。然而，目前尚不清楚线粒体是否以及如何影响人类的长寿。我们进行了这项综述，以确定哪些 SNP 与健康衰老的标志物有关。
我们使用 PRISMA 方法，在 PubMed 和 Embase 数据库中进行了系统综述，以确定 TOMM40 SNP 与长寿和健康衰老的衡量标准之间的关联。
选择了 24 篇文章。TOMM40 SNP rs2075650 和 rs10524523 是与长寿最常被识别和研究的两个 SNP。与 TOMM40 SNP 相关的结果是 BMI、大脑完整性、认知功能、炎症网络改变、血管危险因素易感性和长寿的变化。
我们的系统综述确定了多个可能与健康衰老有关的 TOMM40 SNP。更多的研究可以帮助我们了解衰老的机制，包括弹性、预防疾病和适应环境。
