Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
J Neurosci Res. 2022 Nov;100(11):1969-1986. doi: 10.1002/jnr.25114. Epub 2022 Aug 7.
Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug-resistant patients who are not eligible for palliative surgeries.
抗癫痫药物已成功治疗癫痫并为患者提供持续的无癫痫发作。然而，约 30%的癫痫患者存在药物抵抗，即他们对药物治疗没有反应。有鉴于此，寻求替代治疗方法变得极为重要，以便为这些患者提供适当的治疗，并提高他们的生活质量。有鉴于此，本综述旨在讨论目前正在研究的一些治疗癫痫的创新方法，包括从治疗化合物到临床程序的各种策略。例如，源自动物毒液的肽，如黄蜂、蜘蛛和蝎子的毒液，表现出有希望的抗癫痫分子，作用于多种靶点。其他选择是大麻素和调节内源性大麻素系统的化合物，因为现在已知该网络参与癫痫的病理生理学。此外，神经刺激是另一种策略，对于那些不符合姑息性手术条件的耐药患者来说，这是一种替代的临床程序。
