Sandeep K S, Rathod Priyank, Dalvi Raisha, Pawar Ajinkya, Thottiyen Salahudheen, Pandya Shashank, Sharma Mohit, Patel Shailesh, Warikoo Vikas, Pandya Shivam
Gujarat Cancer and Research Institute, Ahmedabad, India.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):581-586. doi: 10.1007/s12070-023-04216-z. Epub 2023 Oct 8.
Head and neck osteosarcoma is an uncommon yet aggressive tumor which presents therapeutic challenges to get favourable results. Surgery remained the most effective treatment modality in this entity eventhough chemoradiotherapy have been tried in various studies for better outcome but still not yet becomes the standard in the management of these cases unlike in extremity osteosarcoma. We present our experience in the management of this uncommon yet lethal malignant tumor, i.e. head and neck osteosarcoma. To study the clinicopathological and prognostic features of Osteosarcoma in head and neck subsite. Retrospective study of patients diagnosed with head and neck osteosarcoma between 2003 and 2019. Total of 25 patients were included in our study. Mean age of our population is 27.5 years with slight male predominant. Mandible is the most commonly involved site. Multimodal treatment applied with surgical resection forms the main part in the management. Median DFS and OS were 16 and 36 months respectively with 5 year overall survival of 42%. Out of the various factors studied, absence of surgery, margin positivity are the principle features affecting the prognosis. Head and neck osteosarcoma is generally a jaw bone tumor commonly occurs in young adults with poor outcome. Since there is no universal guidelines to address this uncommon tumor, multiple studies have shown various results in the management. Till date, surgery remained the curative modality with mixed response on the role of chemotherapy and radiotherapy.
头颈部骨肉瘤是一种罕见但具有侵袭性的肿瘤，在获得良好治疗效果方面面临着诸多挑战。手术仍然是该疾病最有效的治疗方式，尽管在各项研究中已经尝试了放化疗以取得更好的疗效，但与肢体骨肉瘤不同，放化疗尚未成为这些病例治疗的标准方法。我们展示了我们在治疗这种罕见但致命的恶性肿瘤——头颈部骨肉瘤方面的经验。旨在研究头颈部不同亚部位骨肉瘤的临床病理特征和预后特征。对2003年至2019年间诊断为头颈部骨肉瘤的患者进行回顾性研究。我们的研究共纳入25例患者。研究人群的平均年龄为27.5岁，男性略占主导。下颌骨是最常受累的部位。以手术切除为主的多模式治疗是治疗的主要部分。无病生存期（DFS）和总生存期（OS）的中位数分别为16个月和36个月，5年总生存率为42%。在研究的各种因素中，未进行手术、切缘阳性是影响预后的主要因素。头颈部骨肉瘤通常是一种颌骨肿瘤，常见于年轻人，预后较差。由于目前尚无针对这种罕见肿瘤的通用指南，多项研究在治疗方面显示了不同的结果。迄今为止，手术仍然是治愈性的治疗方式，化疗和放疗的作用效果不一。
