Brown J M, Steffensen A, Trump B
Department of Orthopaedics, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
University of Utah School of Dentistry, Salt Lake City, Utah, USA.
Int J Oral Maxillofac Surg. 2023 May;52(5):524-530. doi: 10.1016/j.ijom.2022.10.005. Epub 2022 Oct 13.
Osteosarcoma is the most common bone sarcoma and is typically found in the distal femur, proximal tibia, and proximal humerus. While several factors are known to influence survival, less is known regarding the influence of primary tumor location. This study describes the clinical features and prognosis of mandibular osteosarcoma. The SEER database was utilized to identify cases of mandibular osteosarcoma diagnosed between 2004 and 2015. Sex, age, grade, histological subtype, tumor size, tumor extension, presence of metastasis at diagnosis, and therapeutic intervention were determined. Osteosarcomas originating from other sites were assessed for comparison. There were 164 cases of mandibular osteosarcoma identified, representing 5.5% of all surveyed osteosarcomas. The 2-, 5-, and 10-year overall survival rates were 79.9%, 65.6% and 58.5%, respectively. Survival was worse for patients with older age, larger tumor size, metastatic disease, and absence of surgical resection. Compared to other sites, mandibular osteosarcomas were significantly smaller tumors and were far less likely to metastasize. Mandibular osteosarcoma manifested at an older age than the more common extremity osteosarcomas and presented with smaller tumors. Rates of metastasis of jaw osteosarcoma were much lower than osteosarcoma found in the extremities, while mortality rates were comparable.
骨肉瘤是最常见的骨肉瘤，通常发生于股骨远端、胫骨近端和肱骨近端。虽然已知有几个因素会影响生存率，但关于原发肿瘤位置的影响了解较少。本研究描述了下颌骨肉瘤的临床特征和预后。利用监测、流行病学与最终结果（SEER）数据库来确定2004年至2015年间诊断为下颌骨肉瘤的病例。确定了性别、年龄、分级、组织学亚型、肿瘤大小、肿瘤侵犯范围、诊断时有无转移以及治疗干预情况。对源自其他部位的骨肉瘤进行评估以作比较。共确定了164例下颌骨肉瘤病例，占所有调查骨肉瘤病例的5.5%。2年、5年和10年总生存率分别为79.9%、65.6%和58.5%。年龄较大、肿瘤较大、有转移性疾病以及未进行手术切除的患者生存率较差。与其他部位相比，下颌骨肉瘤的肿瘤明显较小，转移的可能性也小得多。下颌骨肉瘤的发病年龄比更常见的四肢骨肉瘤大，肿瘤也较小。颌骨骨肉瘤的转移率远低于四肢骨肉瘤，而死亡率相当。
