Islam A
Med Hypotheses. 1985 May;17(1):69-77. doi: 10.1016/0306-9877(85)90021-0.
Chronic granulocytic leukaemia (CGL) is regarded as a myeloproliferative disorder; in the chronic phase, the disease is characterized by excessive proliferation of myeloid cells apparently in the absence of any physiological demand. The reason(s) why and how this purposeless proliferation of myeloid cells begins remains to be elucidated. Recent studies on cellular interaction between stromal and haemopoietic stem cells (HSC) suggests that the stromal cells exert some form of regulatory influence on the growth and differentiation of HSC. In this communication it is postulated that CGL may be the result of a defect in cellular interactions between the stromal and haemopoietic stem cells.
慢性粒细胞白血病（CGL）被视为一种骨髓增殖性疾病；在慢性期，该疾病的特征是骨髓细胞过度增殖，显然是在没有任何生理需求的情况下发生的。骨髓细胞这种无目的增殖为何以及如何开始，仍有待阐明。最近关于基质细胞与造血干细胞（HSC）之间细胞相互作用的研究表明，基质细胞对HSC的生长和分化发挥某种形式的调节作用。在本通讯中，推测CGL可能是基质细胞与造血干细胞之间细胞相互作用缺陷的结果。
