Division of Theory and Practice of Sports and Fields of Physical Activity, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, Bayreuth, Germany.
Division of Exercise Physiology and Metabolism, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, Bayreuth, Germany.
Diabetes Obes Metab. 2024 Sep;26(9):3849-3859. doi: 10.1111/dom.15732. Epub 2024 Jun 25.
AIMS: To investigate how a change in body position with light-intensity physical activity (PA) 'snacks' (LIPAS, alternate sitting and standing, walking or standing continuously) compared with uninterrupted prolonged sitting affects glucose metabolism and heart rate variability (HRV) parameters in young adults with overweight and obesity. MATERIALS AND METHODS: We conducted a four-arm randomized controlled crossover trial. The following conditions were tested during an 8-h simulated workday: uninterrupted prolonged sitting (SIT), alternate sitting and standing (SIT-STAND; 2.5 h total), continuous standing (STAND), and continuous walking (1.0 mph; WALK). The primary outcome was to investigate how a change in body position (alternate sitting and standing, walking or standing continuously) compared with uninterrupted sitting affects mean 8-h glucose metabolism. Secondary outcomes included the effects on 2-h postprandial glucose concentrations, as well as on 8-h/24-h heart rate and HRV parameters, in the respective study arms. Capillary blood samples were drawn from an hyperemised earlobe in the fasted state and once every hour during each trial intervention by puncturing the earlobe with a lancet and collecting 20 μL of blood (Biosen S-Line Lab+; EKF diagnostics, Barleben, Germany). HRV was assessed for 24 h including the 8-h intervention phase, and a home phase by means of a Holter electrocardiogram. All participants received the same standardized non-relativised breakfast and lunch during the four trial visits. RESULTS: Seventeen individuals (eight women, mean age 23.4 ± 3.3 years, body mass index 29.7 ± 3.8 kg/m, glycated haemoglobin level 34.8 ± 3.1 mmol/mol [5.4 ± 0.3%], body fat 31.8 ± 8.2%) completed all four trial arms. Compared with SIT (89.4 ± 6.8 mg/dL), 8-h mean glucose was lower in all other conditions (p < 0.05) and this was statistically significant compared with WALK (86.3 ± 5.2 mg/dL; p = 0.034). Two-hour postprandial glucose after breakfast was approximately 7% lower for WALK compared with SIT (p = 0.002). Furthermore, significant time × condition effects on HRV parameters favouring light-intensity walking were observed (p < 0.001). CONCLUSIONS: Replacement and interruption of prolonged sitting with light-intensity walking showed a significant blood glucose-lowering effect and improved HRV during an 8-h work environment in young adults with overweight and obesity.
目的：研究与不间断长时间坐姿相比，轻强度体力活动（LIPAS，交替坐立和站立、连续行走或站立）中体位变化对超重和肥胖青年的葡萄糖代谢和心率变异性（HRV）参数的影响。
材料和方法：我们进行了一项四项随机对照交叉试验。在模拟 8 小时工作日期间，测试了以下条件：不间断长时间坐姿（SIT）、交替坐立和站立（SIT-STAND；总计 2.5 小时）、连续站立（STAND）和连续行走（1.0 英里/小时；WALK）。主要结果是研究体位变化（交替坐立和站立、连续行走或站立）与不间断坐姿相比如何影响平均 8 小时的葡萄糖代谢。次要结果包括在各自的研究臂中，对 2 小时餐后血糖浓度以及 8 小时/24 小时心率和 HRV 参数的影响。通过刺破耳垂并用柳叶刀采集 20 μL 血液（Biosen S-Line Lab+；EKF diagnostics，Barleben，德国），从空腹状态下充血的耳垂中抽取毛细血管血样。通过 24 小时动态心电图评估 HRV，包括 8 小时干预阶段和家庭阶段。所有参与者在四次试验访问期间都接受了相同的标准化非相对早餐和午餐。
结果：十七名个体（八名女性，平均年龄 23.4±3.3 岁，体重指数 29.7±3.8kg/m，糖化血红蛋白水平 34.8±3.1mmol/mol[5.4±0.3%]，体脂 31.8±8.2%）完成了所有四项试验。与 SIT（89.4±6.8mg/dL）相比，所有其他条件下的 8 小时平均血糖均较低（p<0.05），与 WALK（86.3±5.2mg/dL；p=0.034）相比具有统计学意义。与 SIT 相比，早餐后 2 小时餐后血糖在 WALK 时降低了约 7%（p=0.002）。此外，还观察到有利于轻强度行走的 HRV 参数的显著时间×条件效应（p<0.001）。
结论：在超重和肥胖的青年中，轻强度步行替代和中断长时间坐姿可显著降低血糖，并在 8 小时工作环境中改善 HRV。
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