Division of Theory and Practice of Sports and Fields of Physical Activity, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
Division of Exercise Physiology and Metabolism, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
Biomolecules. 2024 Aug 19;14(8):1029. doi: 10.3390/biom14081029.
Sedentary behavior (SB) is an essential risk factor for obesity, cardiovascular disease, and type 2 diabetes. Though certain levels of physical activity (PA) may attenuate the detrimental effects of SB, the inflammatory and cardiometabolic responses involved are still not fully understood. The focus of this secondary outcome analysis was to describe how light-intensity PA snacks (LIPASs, alternate sitting and standing, walking or standing continuously) compared with uninterrupted prolonged sitting affect inflammatory and cardiometabolic risk markers. Seventeen young adults with overweight and obesity participated in this study (eight females, 23.4 ± 3.3 years, body mass index (BMI) 29.7 ± 3.8 kg/m, glycated hemoglobin A1C (HbA) 5.4 ± 0.3%, body fat 31.8 ± 8.2%). Participants were randomly assigned to the following conditions which were tested during an 8 h simulated workday: uninterrupted prolonged sitting (SIT), alternate sitting and standing (SIT-STAND, 2.5 h total standing time), continuous standing (STAND), and continuous walking (1.6 km/h; WALK). Each condition also included a standardized non-relativized breakfast and lunch. Venous blood samples were obtained in a fasted state at baseline (T), 1 h after lunch (T) and 8 h after baseline (T). Inflammatory and cardiometabolic risk markers included interleukin-6 (IL-6), c-reactive protein (CRP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), visceral fat area (VFA), triglyceride-glucose (TyG) index, two lipid ratio measures, TG/HDL-C and TC/HDL-C, albumin, amylase (pancreatic), total protein, uric acid, and urea. We found significant changes in a broad range of certain inflammatory and cardiometabolic risk markers during the intervention phase for IL-6 ( = 0.014), TG ( = 0.012), TC ( = 0.017), HDL-C ( = 0.020), LDL-C ( = 0.021), albumin ( = 0.003), total protein ( = 0.021), and uric acid ( = 0.040) in favor of light-intensity walking compared with uninterrupted prolonged sitting, alternate sitting and standing, and continuous standing. We found no significant changes in CRP ( = 0.529), creatinine ( = 0.199), TyG ( = 0.331), and the lipid ratios TG/HDL-C ( = 0.793) and TC/HDL-C ( = 0.221) in response to the PA snack. During a simulated 8 h work environment replacement and interruption of prolonged sitting with light-intensity walking, significant positive effects on certain inflammatory and cardiometabolic risk markers were found in young adults with overweight and obesity.
久坐行为（SB）是肥胖、心血管疾病和 2 型糖尿病的一个重要危险因素。虽然一定水平的体力活动（PA）可能会减轻 SB 的有害影响，但涉及的炎症和心血管代谢反应仍不完全清楚。本二次结果分析的重点是描述与不间断的长时间坐姿相比，低强度体力活动零食（LIPASs，交替坐站、连续行走或站立）如何影响炎症和心血管代谢风险标志物。17 名超重和肥胖的年轻人参与了这项研究（8 名女性，23.4±3.3 岁，体重指数（BMI）29.7±3.8kg/m，糖化血红蛋白 A1C（HbA）5.4±0.3%，体脂 31.8±8.2%）。参与者被随机分配到以下条件下，在 8 小时模拟工作日中进行测试：不间断的长时间坐姿（SIT）、交替坐站（SIT-STAND，总站立时间 2.5 小时）、连续站立（STAND）和连续行走（1.6km/h；WALK）。每个条件还包括标准化的非相对化早餐和午餐。在禁食状态下，在基线（T）、午餐后 1 小时（T）和基线后 8 小时（T）采集静脉血样。炎症和心血管代谢风险标志物包括白细胞介素-6（IL-6）、C 反应蛋白（CRP）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TGs）、内脏脂肪面积（VFA）、甘油三酯-葡萄糖（TyG）指数、两种血脂比测量、TG/HDL-C 和 TC/HDL-C、白蛋白、淀粉酶（胰腺）、总蛋白、尿酸和尿素。我们发现，在干预阶段，与不间断的长时间坐姿、交替坐站和连续站立相比，IL-6（=0.014）、TG（=0.012）、TC（=0.017）、HDL-C（=0.020）、LDL-C（=0.021）、白蛋白（=0.003）、总蛋白（=0.021）和尿酸（=0.040）等多种炎症和心血管代谢风险标志物有显著变化。我们发现，C 反应蛋白（=0.529）、肌酐（=0.199）、TyG（=0.331）和血脂比 TG/HDL-C（=0.793）和 TC/HDL-C（=0.221）在 PA 零食的作用下没有明显变化。在模拟 8 小时工作环境中，用低强度步行替代和中断长时间坐姿，超重和肥胖的年轻人的某些炎症和心血管代谢风险标志物有显著的积极变化。
