Health Management Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China.
School of Laboratory Medicine, Youjiang Medical University for Nationalities, Guangxi, China.
J Cell Mol Med. 2024 Jun;28(12):e18468. doi: 10.1111/jcmm.18468.
IL33 plays an important role in cancer. However, the role of liver cancer remains unclear. Open-accessed data was obtained from the Cancer Genome Atlas, Xena, and TISCH databases. Different algorithms and R packages are used to perform various analyses. Here, in our comprehensive study on IL33 in HCC, we observed its differential expression across cancers, implicating its role in cancer development. The single-cell analysis highlighted its primary expression in endothelial cells, unveiling correlations within the HCC microenvironment. Also, the expression level of IL33 was correlated with patients survival, emphasizing its potential prognostic value. Biological enrichment analyses revealed associations with stem cell division, angiogenesis, and inflammatory response. IL33's impact on the immune microenvironment showcased correlations with diverse immune cells. Genomic features and drug sensitivity analyses provided insights into IL33's broader implications. In a pan-cancer context, IL33 emerged as a potential tumour-inhibitor, influencing immune-related molecules. This study significantly advances our understanding of IL33 in cancer biology. IL33 exhibited differential expression across cancers, particularly in endothelial cells within the HCC microenvironment. IL33 is correlated with the survival of HCC patients, indicating potential prognostic value and highlighting its broader implications in cancer biology.
IL33 在癌症中发挥着重要作用。然而，肝癌的作用仍不清楚。本研究从癌症基因组图谱（Cancer Genome Atlas）、Xena 和 TISCH 数据库中获取了公开访问的数据。使用不同的算法和 R 包来执行各种分析。在本研究中，我们对 HCC 中的 IL33 进行了全面研究，观察到其在癌症中的差异表达，表明其在癌症发展中的作用。单细胞分析突出了其在内皮细胞中的主要表达，揭示了 HCC 微环境中的相关性。此外，IL33 的表达水平与患者的生存相关，强调了其潜在的预后价值。生物富集分析显示与干细胞分裂、血管生成和炎症反应有关。IL33 对免疫微环境的影响显示与多种免疫细胞相关。基因组特征和药物敏感性分析提供了对 IL33 更广泛影响的深入了解。在泛癌症背景下，IL33 作为一种潜在的肿瘤抑制剂，影响免疫相关分子。本研究显著提高了我们对癌症生物学中 IL33 的认识。IL33 在癌症中表现出差异表达，特别是在 HCC 微环境中的内皮细胞中。IL33 与 HCC 患者的生存相关，表明其具有潜在的预后价值，并突出了其在癌症生物学中的更广泛意义。
