Department of Cardiology, Seventh People's Hospital of Zhengzhou, Henan Provincial Key Laboratory of Arrhythmia, Henan Key Laboratory of Cardiac Remodeling and Transplantation, Zhengzhou, China.
Department of Endocrinology Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
PLoS One. 2024 Jun 26;19(6):e0300795. doi: 10.1371/journal.pone.0300795. eCollection 2024.
Copper (Cu) homeostasis are important processes in the cause of metabolic diseases, but the association between Cu and obesity remains unclear.
Participants were drawn from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression assessed the associations of serum Cu concentrations (tertiles) with obesity and central obesity in individuals without comorbidities. Obesity was defined as a BMI ≥30.0 kg/m2, and central obesity was defined as a waist circumference ≥80 cm for women and ≥95 cm for men.
This cross-sectional study included 1,665 adults without comorbidities, representing 24,744,034 people (mean age 35.1 years, 48.5% female). High serum Cu levels (tertile 3: ≥19.19 μmol/L) were associated with higher odds of obesity (adjusted odds ratio [OR]: 4.48, 95% CI[confidence interval]: 2.44-8.32) and central obesity (OR: 2.36, 95% CI: 1.19-4.66) compared to low serum Cu levels (tertile 1: ≤15.64 μmol/L). The dose-response curve showed a nonlinear association between Cu levels and obesity (P-nonlinear = 0.02) and a linear association with central obesity (P-nonlinear = 0.21).
This study suggests that higher serum Cu levels are associated with increased odds of obesity in healthy American adults.
铜（Cu）稳态是代谢性疾病发病机制中的重要过程，但 Cu 与肥胖之间的关系尚不清楚。
参与者来自 2011-2016 年全国健康和营养调查（NHANES）。加权逻辑回归评估了血清 Cu 浓度（三分位）与无合并症个体肥胖和中心性肥胖的关系。肥胖定义为 BMI≥30.0kg/m2，中心性肥胖定义为女性腰围≥80cm，男性腰围≥95cm。
这项横断面研究纳入了 1665 名无合并症的成年人，代表了 24744034 人（平均年龄 35.1 岁，48.5%为女性）。高血清 Cu 水平（三分位 3：≥19.19μmol/L）与肥胖（调整后比值比 [OR]：4.48，95%置信区间 [CI]：2.44-8.32）和中心性肥胖（OR：2.36，95%CI：1.19-4.66）的几率较高相关，与低血清 Cu 水平（三分位 1：≤15.64μmol/L）相比。剂量-反应曲线显示 Cu 水平与肥胖之间存在非线性关联（P-非线性=0.02），与中心性肥胖之间存在线性关联（P-非线性=0.21）。
本研究表明，较高的血清 Cu 水平与美国健康成年人肥胖的几率增加有关。
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