State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China.
FASEB J. 2024 Jul 15;38(13):e23767. doi: 10.1096/fj.202400739R.
Macrophages possess a diverse range of well-defined capabilities and roles as phagocytes, encompassing the regulation of inflammation, facilitation of wound healing, maintenance of tissue homeostasis, and serving as a crucial element in the innate immune response against microbial pathogens. The emergence of extracellular traps is a novel strategy of defense that has been observed in several types of innate immune cells. In response to infection, macrophages are stimulated and produce macrophage extracellular traps (METs), which take the form of net-like structures, filled with strands of DNA and adorned with histones and other cellular proteins. METs not only capture and eliminate microorganisms but also play a role in the development of certain diseases such as inflammation and autoimmune disorders. The primary objective of this study is to examine the latest advancements in METs for tackling bacterial infections. We also delve into the current knowledge and tactics utilized by bacteria to elude or endure the effects of METs. Through this investigation, we hope to shed light on the intricate interactions between bacteria and the host's immune system, particularly in the context of microbicidal effector mechanisms of METs. The continued exploration of METs and their impact on host defense against various pathogens opens up new avenues for understanding and potentially manipulating the immune system's response to infections.
巨噬细胞作为吞噬细胞，具有多种明确的功能和作用，包括调节炎症、促进伤口愈合、维持组织内稳态以及作为先天免疫反应抵抗微生物病原体的关键因素。细胞外陷阱的出现是一种新的防御策略，已经在几种类型的先天免疫细胞中观察到。在受到感染时，巨噬细胞受到刺激并产生巨噬细胞细胞外陷阱（METs），其形式为网状结构，充满 DNA 链，并饰有史坦和其他细胞蛋白。METs 不仅可以捕获和消除微生物，而且在炎症和自身免疫性疾病等某些疾病的发展中发挥作用。本研究的主要目的是研究 METs 在应对细菌感染方面的最新进展。我们还深入探讨了细菌用来躲避或耐受 METs 影响的现有知识和策略。通过这项研究，我们希望揭示细菌与宿主免疫系统之间复杂的相互作用，特别是在 METs 的杀菌效应机制方面。对 METs 及其对宿主防御各种病原体的影响的持续探索为理解和潜在操纵免疫系统对感染的反应开辟了新途径。
