Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of brain function and cognitive magnetic resonance imaging, China; Henan Engineering Technology Research Center for detection and application of brain function, China; Henan Engineering Research Center of medical imaging intelligent diagnosis and treatment, China; Henan key laboratory of imaging intelligence research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Addict Behav. 2024 Oct;157:108088. doi: 10.1016/j.addbeh.2024.108088. Epub 2024 Jun 15.
The incidence of behavioral addictions (BAs) associated with scientific and technological advances has been increasing steadily. Unfortunately, a large number of studies on the structural and functional abnormalities have shown poor reproducibility, and it remains unclear whether different addictive behaviors share common underlying abnormalities. Therefore, our objective was to conduct a quantitative meta-analysis of different behavioral addictions to provide evidence-based evidence of common structural and functional changes.
We conducted systematic searches in PubMed, Web of Science and Scopus from January 2010 to December 2023, supplementing reference lists of high-quality relevant meta-analyses and reviews, to identify eligible voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies. Using anisotropic seed-based D-Mapping (AES-SDM) meta-analysis methods, we compared brain abnormalities between BAs and healthy controls (HCs).
There were 11 GMV studies (287 BAs and 292 HCs) and 26 fMRI studies (577 BAs and 545 HCs) that met inclusion criteria. Compared with HCs, BAs demonstrated significant reductions in gray matter volume (GMV) in (1) right anterior cingulate gyri extending into the adjacent superior frontal gyrus, as well as in the left inferior frontal gyrus and right striatum. (2) the bilateral precuneus, right supramarginal gyrus, and right fusiform gyrus were hyperfunction; (3) the left medial cingulate gyrus extended to the superior frontal gyrus, the left inferior frontal gyrus, and right middle temporal gyrus had hypofunction.
Our study identified structural and functional impairments in brain regions involved in executive control, cognitive function, visual memory, and reward-driven behavior in BAs. Notably, fronto-cingulate regions may serve as common biomarkers of BAs.
随着科技进步，与行为成瘾相关的发病率一直在稳步上升。不幸的是，大量关于结构和功能异常的研究显示出较差的可重复性，并且尚不清楚不同的成瘾行为是否具有共同的潜在异常。因此，我们的目标是对不同的行为成瘾进行定量荟萃分析，提供行为成瘾的结构和功能变化的循证证据。
我们从 2010 年 1 月至 2023 年 12 月在 PubMed、Web of Science 和 Scopus 进行了系统搜索，补充了高质量相关荟萃分析和综述的参考文献列表，以确定符合条件的基于体素的形态测量学（VBM）和功能磁共振成像（fMRI）研究。使用各向异性种子基 D-Mapping（AES-SDM）荟萃分析方法，我们比较了行为成瘾与健康对照组（HCs）之间的大脑异常。
有 11 项 GMV 研究（287 名行为成瘾者和 292 名 HCs）和 26 项 fMRI 研究（577 名行为成瘾者和 545 名 HCs）符合纳入标准。与 HCs 相比，行为成瘾者表现出以下脑区灰质体积（GMV）显著减少：（1）右侧前扣带回延伸到相邻的额上回，以及左侧额下回和右侧纹状体；（2）双侧楔前叶、右侧缘上回和右侧梭状回功能亢进；（3）左侧扣带回延伸到额上回、左侧额下回和右侧颞中回功能低下。
我们的研究发现行为成瘾者的大脑区域在执行控制、认知功能、视觉记忆和奖励驱动行为方面存在结构和功能损伤。值得注意的是，额扣带区域可能是行为成瘾的共同生物标志物。
