Niu Xiaoyu, Gao Xinyu, Zhang Mengzhe, Yang Zhengui, Yu Miaomiao, Wang Weijian, Wei Yarui, Cheng Jingliang, Han Shaoqiang, Zhang Yong
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henan Key Laboratory of Magnetic Resonance and Brain Function, Zhengzhou, China.
Front Psychiatry. 2022 Oct 25;13:1029344. doi: 10.3389/fpsyt.2022.1029344. eCollection 2022.
Many neuroimaging studies have reported abnormalities in brain structure and function in internet gaming disorder (IGD). However, the findings were divergent. We aimed to provide evidence-based evidence of structural and functional changes in IGD by conducting a meta-analysis integrating these studies quantitatively.
A systematic search was conducted in PubMed, ScienceDirect, Web of Science, and Scopus from January 1, 2010 to October 31, 2021, to identify eligible voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies. Brain alternations between IGD subjects and healthy controls (HCs) were compared using the anisotropic seed-based d mapping (AES-SDM) meta-analytic method. Meta-regression analysis was used to investigate the relationship between gray matter volume (GMV) alterations and addiction-related clinical features.
The meta-analysis contained 15 VBM studies (422 IGD patients and 354 HCs) and 30 task-state fMRI studies (617 IGD patients and 550 HCs). Compared with HCs, IGD subjects showed: (1) reduced GMV in the bilateral anterior/median cingulate cortex, superior/inferior frontal gyrus and supplementary motor area; (2) hyperactivation in the bilateral inferior frontal gyrus, precentral gyrus, left precuneus, right inferior temporal gyrus and right fusiform; (3) hypoactivation in the bilateral lingual and the left middle frontal gyrus; and (4) both decreased GMV and increased activation in the left anterior cingulate. Furthermore, Meta-regression revealed that GMV reduction in left anterior cingulate were positively correlated with BIS-11 score [ = 0.725, = 0.012(uncorrected)] and IAT score [ = 0.761, = 0.017(uncorrected)].
This meta-analysis showed structural and functional impairments in brain regions related to executive control, cognitive function and reward-based decision making in IGD. Furthermore, multi-domain assessments captured different aspects of neuronal changes in IGD, which may help develop effective interventions as potential therapeutic targets.
许多神经影像学研究报告了网络成瘾障碍（IGD）患者脑结构和功能的异常。然而，研究结果存在分歧。我们旨在通过对这些研究进行定量整合的荟萃分析，为IGD的结构和功能变化提供循证依据。
于2010年1月1日至2021年10月31日在PubMed、ScienceDirect、Web of Science和Scopus数据库中进行系统检索，以确定符合条件的基于体素的形态学测量（VBM）和功能磁共振成像（fMRI）研究。采用基于各向异性种子点的d映射（AES-SDM）荟萃分析方法比较IGD患者与健康对照（HCs）之间的脑差异。采用荟萃回归分析研究灰质体积（GMV）改变与成瘾相关临床特征之间的关系。
荟萃分析纳入了15项VBM研究（422例IGD患者和354例HCs）和30项任务态fMRI研究（617例IGD患者和550例HCs）。与HCs相比，IGD患者表现为：（1）双侧前扣带回/中央前回、额上/下回及辅助运动区GMV减少；（2）双侧额下回、中央前回、左侧楔前叶、右侧颞下回及右侧梭状回激活增强；（3）双侧舌回及左侧额中回激活减弱；（4）左侧前扣带回GMV减少且激活增强。此外，荟萃回归显示，左侧前扣带回GMV减少与BIS-11评分[β = 0.725，P = 0.012（未校正）]和IAT评分[β = 0.761，P = 0.017（未校正）]呈正相关。
该荟萃分析显示IGD患者在与执行控制、认知功能和基于奖励的决策相关的脑区存在结构和功能损害。此外，多领域评估捕捉到了IGD神经元变化的不同方面，这可能有助于开发有效的干预措施作为潜在的治疗靶点。
