National Engineering Laboratory for Deep Process of Rice and Byproducts, Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
National Engineering Laboratory for Deep Process of Rice and Byproducts, Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Redox Biol. 2024 Sep;75:103252. doi: 10.1016/j.redox.2024.103252. Epub 2024 Jun 22.
Pulmonary vascular remodeling and inflammation play an important role in the hypoxic-induced lung diseases. Our previous investigations showed that peptide from yak milk residues could alleviate inflammation. In this study, our results suggest that peptide (LV) from yak milk residues peptide had protective effect of lung in the animal models of hypoxic-induced lung injury. LV Gavage could improve pulmonary vascular remodeling in the lung tissues of hypoxic mice. A comprehensive analysis of metabolomics and transcriptomics revealed that 5-KETE, 8,9-EET, and 6-keto-prostaglandin F1a might be potential targets to prevent lung injury in the hypoxic mice. These metabolites can be regulated by MAPK/VEGF and inflammatory pathways. Our data indicated that LV treatment could inhibit apoptosis and inflammation via Nrf2/NF-κB/MAPK/PHD-2 pathway and protected hypoxic-induced lung epithelial cells injury. Taken together, our results suggest that LV provides a novel therapeutic clue for the prevention of hypoxia-induced lung injury and inflammation-related lung diseases.
肺血管重构和炎症在低氧诱导的肺部疾病中起着重要作用。我们之前的研究表明，牦牛乳肽可以缓解炎症。在这项研究中，我们的结果表明，牦牛乳肽 LV 对低氧诱导肺损伤的动物模型具有肺保护作用。LV 灌胃可以改善低氧小鼠肺组织中的肺血管重构。代谢组学和转录组学的综合分析表明，5-KETE、8,9-EET 和 6-酮-前列腺素 F1a 可能是预防低氧小鼠肺损伤的潜在靶点。这些代谢物可以通过 MAPK/VEGF 和炎症途径进行调节。我们的数据表明，LV 通过 Nrf2/NF-κB/MAPK/PHD-2 通路抑制细胞凋亡和炎症，保护低氧诱导的肺上皮细胞损伤。综上所述，我们的研究结果表明，LV 为预防低氧诱导的肺损伤和炎症相关肺部疾病提供了新的治疗线索。
