Department of Dermatology, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands
Department of Dermatology, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands.
BMJ Open. 2024 Jun 25;14(6):e081280. doi: 10.1136/bmjopen-2023-081280.
Children with atopic dermatitis (AD) are more at risk for the neurodevelopmental disorders attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) with parallel increases in global prevalences. Children afflicted with these conditions appear to share similar problems in sensory modulation but investigational studies on the underlying aetiology are scarce. This scoping review aims to find knowledge gaps, collate hypotheses and to summarise available evidence on the shared pathophysiology of AD, ADHD and ASD in children.
Our study will follow the methodological manual published by the Joanna Briggs Methodology for Scoping Reviews and will be reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews. The following electronic databases will be searched for studies focused on children with AD and symptoms of ADHD and/or ASD: Medline ALL via Ovid, Embase, Web of Science Core Collection and the Cochrane Central Register of Controlled Trials via Wiley.
This review does not require ethics approval as it will not be conducted with human participants. We will only use published data. Our dissemination strategy includes peer review publication and conference reports.
患有特应性皮炎（AD）的儿童患注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）等神经发育障碍的风险更高，而这些疾病的全球患病率也在平行上升。受这些疾病影响的儿童似乎在感觉调节方面存在相似的问题，但关于潜在病因的研究却很少。本范围综述旨在发现知识空白，整理假说，并总结有关儿童 AD、ADHD 和 ASD 共同病理生理学的现有证据。
我们的研究将遵循 Joanna Briggs 方法学发表的范围综述方法手册，并按照系统评价和 Meta 分析扩展的首选报告项目进行报告。将在以下电子数据库中搜索针对患有 AD 且有 ADHD 和/或 ASD 症状的儿童的研究：通过 Ovid 进行 Medline ALL、Embase、Web of Science 核心合集以及 Wiley 上的 Cochrane 对照试验中心注册。
由于本综述不涉及人类参与者，因此不需要伦理批准。我们将只使用已发表的数据。我们的传播策略包括同行评审发表和会议报告。
