Eaves E R, Hansky J, Korman M G
Regul Pept. 1985 May;11(1):1-10. doi: 10.1016/0167-0115(85)90025-4.
This study investigated the food stimulated release of neurotensin-like immunoreactivity (NTLI) in man with and without the administration of atropine, and the influence of vagal stimulation by modified sham feeding and insulin hypoglycaemia. NTLI was measured, after ethanol extraction, by specific C- and N-terminally directed antisera. With both a liquid fat meal and a mixed meal an early peak of NTLI occurred. The mixed meal also produced a second sustained rise in plasma NTLI. An intramuscular injection of 0.6 mg atropine sulphate abolished the early peak, but had no effect on the late peak. Modified sham feeding and insulin hypoglycaemia did not release NTLI. We conclude that it is possible that a cholinergic non-vagal mechanism is responsible for the early phase of food stimulated release of NTLI in man, and that the second sustained rise may be cholinergically independent.
本研究调查了在给予和未给予阿托品的情况下，食物刺激人体释放神经降压素样免疫反应物质（NTLI）的情况，以及改良假饲和胰岛素低血糖引起的迷走神经刺激的影响。乙醇提取后，通过特异性的C端和N端定向抗血清测量NTLI。给予液体脂肪餐和混合餐时，NTLI均出现早期峰值。混合餐还使血浆NTLI出现第二次持续升高。肌肉注射0.6mg硫酸阿托品消除了早期峰值，但对晚期峰值无影响。改良假饲和胰岛素低血糖未释放NTLI。我们得出结论，在人体中，食物刺激NTLI释放的早期阶段可能由胆碱能非迷走神经机制介导，而第二次持续升高可能与胆碱能无关。
