Schafmayer A, Nustede R, Pompino A, Köhler H
Dept. of General Surgery, University of Göttingen, FRG.
Scand J Gastroenterol. 1988 Apr;23(3):315-20. doi: 10.3109/00365528809093872.
Cholecystokinin (CCK) release in seven conscious dogs was investigated by means of modified sham feeding. After sham feeding mean CCK concentrations rose from a basal value of 1.0 +/- 0.2 pmol/l to a peak value of 2.4 +/- 0.3 pmol/l (p less than 0.005). The release in response to sham feeding amounted to half of that seen after normal feeding. Atropine significantly altered CCK output after sham feeding (basal, 1.0 +/- 0.2 pmol/l; peak 1.3 +/- 0.3 pmol/l). Sham feeding did not affect neurotensin release. It is concluded that an important cephalic phase of CCK release exists which seems to be dependent on a cholinergic mechanism.
通过改良假饲法研究了7只清醒犬的胆囊收缩素（CCK）释放情况。假饲后，CCK平均浓度从基础值1.0±0.2 pmol/L升至峰值2.4±0.3 pmol/L（p<0.005）。假饲引起的释放量相当于正常进食后释放量的一半。阿托品显著改变了假饲后的CCK分泌量（基础值，1.0±0.2 pmol/L；峰值1.3±0.3 pmol/L）。假饲不影响神经降压素的释放。结论是存在一个重要的CCK释放头期，这似乎依赖于胆碱能机制。
