3-O-酰化胆汁酸：代谢的干扰者还是协调者？
3-O-acylated bile acids: disrupters or harmonizers of metabolism?
作者信息
Chen Runzhi, Chen Xinhua, Gao Jiangtao
机构信息
Key BioAI Synthetica Lab for Natural Product Drug Discovery, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
出版信息
Trends Mol Med. 2025 Feb;31(2):103-105. doi: 10.1016/j.molmed.2024.06.003. Epub 2024 Jun 25.
Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
本文揭示了一个代谢之谜，探讨了分别由肠道微生物均匀拟杆菌和微小克里斯滕森菌修饰的3-O-酰化胆汁酸，即3-O-琥珀酰化胆酸（3-sucCA）和3-乙酰化胆酸（3-acetyCA），如何可能破坏或协调我们的代谢过程，为代谢功能障碍相关脂肪性肝炎（MASH）和2型糖尿病（T2D）等病症提供新的治疗途径。
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