Milentijević Milica, Katanić Nataša, Joksimović Bojan, Pavlović Aleksandar, Filimonović Jelena, Anđelković Milena, Bojović Ksenija, Elek Zlatan, Ristić Siniša, Vasiljević Miloš, Stevanović Jasmina, Radomirović Danica, Elez-Burnjaković Nikolina, Lalović Nenad, Kulić Milan, Kulić Jovan, Milić Marija
Department of Infective Diseases, Faculty of Medicine, University of Pristina Temporarily Settled in Kosovska Mitrovica, 38220 Kosovska Mitrovica, Serbia.
Clinical Hospital Center Kosovska Mitrovica, 38220 Kosovska Mitrovica, Serbia.
Biomedicines. 2024 Jun 10;12(6):1281. doi: 10.3390/biomedicines12061281.
Severe coagulation abnormalities are common in patients with COVID-19 infection. We aimed to investigate the relationship between pro-inflammatory cytokines and coagulation parameters concerning socio-demographic, clinical, and laboratory characteristics. Our study included patients hospitalized during the second wave of COVID-19 in the Republic of Serbia. We collected socio-demographic, clinical, and blood-sample data for all patients. Cytokine levels were measured using flow cytometry. We analyzed data from 113 COVID-19 patients with an average age of 58.15 years, of whom 79 (69.9%) were male. Longer duration of COVID-19 symptoms before hospitalization (B = 69.672; = 0.002) and use of meropenem (B = 1237.220; = 0.014) were predictive of higher D-dimer values. Among cytokines, higher IL-5 values significantly predicted higher INR values (B = 0.152; = 0.040) and longer prothrombin times (B = 0.412; = 0.043), and higher IL-6 (B = 0.137; = 0.003) predicted longer prothrombin times. Lower IL-17F concentrations at admission (B = 0.024; = 0.050) were predictive of higher INR values, and lower IFN-γ values (B = -0.306; = 0.017) were predictive of higher aPTT values. Our findings indicate a significant correlation between pro-inflammatory cytokines and coagulation-related parameters. Factors such as the patient's level of education, gender, oxygen-therapy use, symptom duration before hospitalization, meropenem use, and serum concentrations of IL-5, IL-6, IL-17F, and IFN-γ were associated with worse coagulation-related parameters.
严重凝血异常在新型冠状病毒肺炎（COVID-19）感染患者中很常见。我们旨在研究促炎细胞因子与凝血参数之间的关系，涉及社会人口统计学、临床和实验室特征。我们的研究纳入了塞尔维亚共和国第二波COVID-19疫情期间住院的患者。我们收集了所有患者的社会人口统计学、临床和血液样本数据。使用流式细胞术测量细胞因子水平。我们分析了113例COVID-19患者的数据，平均年龄为58.15岁，其中79例（69.9%）为男性。住院前COVID-19症状持续时间较长（B = 69.672；P = 0.002）和使用美罗培南（B = 1237.220；P = 0.014）可预测D-二聚体值较高。在细胞因子中，较高的白细胞介素-5（IL-5）值显著预测较高的国际标准化比值（INR）值（B = 0.152；P = 0.040）和较长的凝血酶原时间（B = 0.412；P = 0.043），较高的白细胞介素-6（IL-6）（B = 0.137；P = 0.003）预测较长的凝血酶原时间。入院时较低的白细胞介素-17F（IL-17F）浓度（B = 0.024；P = 0.050）可预测较高的INR值，较低的干扰素-γ（IFN-γ）值（B = -0.306；P = 0.017）可预测较高的活化部分凝血活酶时间（aPTT）值。我们的研究结果表明促炎细胞因子与凝血相关参数之间存在显著相关性。患者的教育程度、性别、氧疗使用情况、住院前症状持续时间、美罗培南使用情况以及IL-5、IL-6、IL-17F和IFN-γ的血清浓度等因素与较差的凝血相关参数有关。
