Department of Cardiology, Medical University of Lublin, 20-059 Lublin, Poland.
Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
Int J Mol Sci. 2024 Jun 11;25(12):6430. doi: 10.3390/ijms25126430.
Coronary artery disease (CAD) and hypertension significantly contribute to cardiovascular morbidity and mortality. MicroRNAs (miRNAs) have recently emerged as promising biomarkers and therapeutic targets for these conditions. This systematic review conducts a thorough analysis of the literature, with a specific focus on investigating miRNA expression patterns in patients with CAD and hypertension. This review encompasses an unspecified number of eligible studies that employed a variety of patient demographics and research methodologies, resulting in diverse miRNA expression profiles. This review highlights the complex involvement of miRNAs in CAD and hypertension and the potential for advances in diagnostic and therapeutic strategies. Future research endeavors are imperative to validate these findings and elucidate the precise roles of miRNAs in disease progression, offering promising avenues for innovative diagnostic tools and targeted interventions.
冠心病(CAD)和高血压是心血管发病率和死亡率的主要原因。微小 RNA(miRNA)最近成为这些疾病有希望的生物标志物和治疗靶点。本系统综述对文献进行了全面分析,特别关注了 CAD 和高血压患者的 miRNA 表达模式。本综述涵盖了使用各种患者人群和研究方法的数量不明的合格研究,产生了不同的 miRNA 表达谱。本综述强调了 miRNA 在 CAD 和高血压中的复杂作用以及在诊断和治疗策略方面取得进展的潜力。未来的研究工作对于验证这些发现并阐明 miRNA 在疾病进展中的确切作用至关重要,为创新的诊断工具和靶向干预提供了有希望的途径。