Department of Psychiatry and Psychotherapy, Technische Universität Dresden, 01307 Dresden, Germany.
Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Int J Mol Sci. 2024 Jun 18;25(12):6666. doi: 10.3390/ijms25126666.
S/S carriers of have been found to be more risk seeking for losses compared to L/L carriers. This finding may be the result of reduced top-down control from the frontal cortex due to altered signal pathways involving the amygdala and ventral striatum. The serotonergic system is known to be involved in neurodevelopment and neuroplasticity. Therefore, the aim of this study was to investigate whether structural differences in white matter can explain the differences in risk-seeking behaviour. Lower structural connectivity in S/S compared to L/L carriers and a negative relationship between risk seeking for losses and connectivity were assumed. Diffusion-weighted imaging was used to compute diffusion parameters for the frontostriatal and uncinate tract in 175 genotyped individuals. The results showed no significant relationship between diffusion parameters and risk seeking for losses. Furthermore, we did not find significant differences in diffusion parameters of the S/S vs. L/L group. There were only group differences in the frontostriatal tract showing stronger structural connectivity in the S/L group, which is also reflected in the whole brain approach. Therefore, the data do not support the hypothesis that the association between and risk seeking for losses is related to differences in white matter pathways implicated in decision-making.
已发现 S/S 携带者比 L/L 携带者更倾向于冒险损失。这一发现可能是由于涉及杏仁核和腹侧纹状体的信号通路改变，导致额叶皮层自上而下的控制减弱所致。5-羟色胺能系统被认为与神经发育和神经可塑性有关。因此，本研究旨在探讨白质结构差异是否可以解释冒险行为的差异。假设 S/S 携带者的结构连接性低于 L/L 携带者，且冒险损失与连接性呈负相关。弥散加权成像用于计算 175 名基因分型个体的额纹状体和钩束的弥散参数。结果显示，弥散参数与冒险损失之间没有显著关系。此外，我们没有发现 S/S 组与 L/L 组之间的扩散参数有显著差异。只有额纹状体束存在组间差异，S/L 组的结构连接性更强，这也反映在全脑方法中。因此，数据不支持这样的假设，即 与冒险损失之间的关联与决策相关的白质通路的差异有关。
