Basic-Jukic Nikolina, Androvic Alen, Beck David, Radunovic Danilo, Juric Ivana, Furic-Cunko Vesna, Katalinic Lea, Sabljic Zoran, Fistrek-Prlic Margareta, Atic Armin, Kljajic Marina, Jelakovic Bojan
Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
J Clin Med. 2024 Jun 7;13(12):3366. doi: 10.3390/jcm13123366.
: The aim of this multicentre retrospective study is to determine the incidence, etiology, clinical characteristics, and outcomes of kidney transplant recipients diagnosed and treated for acute pancreatitis. : We analyzed data from kidney transplant recipients who received kidney allografts between October 1973 and December 2023 and were diagnosed and treated for acute pancreatitis. : Of 2482 patients who received kidney allografts, 10 (0.4%) (5 male) were diagnosed with acute pancreatitis, with a mean age of 48.6 years. Patients were diagnosed with acute pancreatitis between 3 weeks and 24 years after the transplantation. Possible etiologies included cholecystolithiasis, COVID-19, hypercalcemia, postprocedural, use of cannabis, trimetoprim-sulphometoxasole, statins, sirolimus, tacrolimus and obesity. There was no suspected etiology in two patients. Patients were treated with aggressive hydration, pain alleviation and antibiotics if indicated. Four patients developed complications. Local complications included peripancreatic collections, pseudocyst, and abscesses formation, while systemic complications occurred in the form of Cytomegalovirus (CMV) reactivation and urinary tract infection. All patients survived with preserved kidney allograft function. : Acute pancreatitis in kidney transplant recipients is rare. However, it may be linked to significant morbidity and mortality. While symptoms may be nonspecific and brought on by a variety of viral and non-infectious illnesses, as well as adverse effects from immunosuppressive medications, a high degree of awareness is required.
本多中心回顾性研究的目的是确定肾移植受者中被诊断并接受急性胰腺炎治疗的发病率、病因、临床特征和预后。我们分析了1973年10月至2023年12月期间接受同种异体肾移植并被诊断和治疗急性胰腺炎的肾移植受者的数据。在2482例接受同种异体肾移植的患者中，10例（0.4%）（5例男性）被诊断为急性胰腺炎，平均年龄为48.6岁。患者在移植后3周至24年被诊断为急性胰腺炎。可能的病因包括胆囊结石、新冠病毒感染、高钙血症、术后因素、使用大麻、甲氧苄啶 - 磺胺甲恶唑、他汀类药物、西罗莫司、他克莫司和肥胖。两名患者未发现可疑病因。如有指征，患者接受积极补液、止痛和抗生素治疗。4例患者出现并发症。局部并发症包括胰周积液、假性囊肿和脓肿形成，而全身并发症表现为巨细胞病毒（CMV）再激活和尿路感染。所有患者均存活，移植肾肾功能保留。肾移植受者中的急性胰腺炎很少见。然而，它可能与显著的发病率和死亡率相关。虽然症状可能是非特异性的，由多种病毒和非感染性疾病以及免疫抑制药物的不良反应引起，但仍需要高度警惕。
