皮下注射生长激素替代疗法相比肌肉注射，血浆中生长调节素A（生物学活性）和C（免疫活性）水平更高。

Higher plasma somatomedin A (biological) and C (immunological) levels with sc than with im growth hormone replacement therapy.

作者信息

Christiansen J S, Kastrup K W, Alberti K G, Petersen K E, Christiansen C, Orskov H

出版信息

Acta Endocrinol (Copenh). 1985 Jun;109(2):169-72. doi: 10.1530/acta.0.1090169.

DOI:10.1530/acta.0.1090169

Abstract

In a short-term cross-over study the effect of daily sc human growth hormone was compared with that of thrice weekly im treatment. At the end of each 6-week treatment period the 10 growth hormone deficient children were admitted to hospital for evaluation of diurnal plasma levels of hormones and intermediary metabolites. Somatomedin A as well as C levels were higher in 9 of 10 children after sc than after im growth hormone therapy. This may be the basis for previous observations of improved growth after change to sc treatment.

摘要

在一项短期交叉研究中，比较了每日皮下注射人生长激素与每周三次肌肉注射治疗的效果。在每个为期6周的治疗期结束时，10名生长激素缺乏儿童入院，以评估激素和中间代谢产物的昼夜血浆水平。皮下注射生长激素治疗后，10名儿童中有9名的生长调节素A和C水平高于肌肉注射生长激素治疗后。这可能是先前观察到改为皮下注射治疗后生长改善的基础。