Hibi I, Tanaka T, Yano H, Umezawa S, Kagawa J, Tanae A, Ishikawa E
National Children's Medical Research Centre, Tokyo, Japan.
Acta Paediatr Scand Suppl. 1987;337:87-92. doi: 10.1111/j.1651-2227.1987.tb17134.x.
In 25 patients with hGH deficiency, who had been treated long-term with hGH, the mode of hGH administration was switched from the conventional method (0.3-0.5 IU/kg/week, in two or three divided doses, intramuscularly) to daily subcutaneous injection at 1900-2100 hours with a dose of 0.46 +/- 0.07 IU/kg/week (equivalent to 14.7 +/- 2.0 IU/m2/week). After 1-3 months of this new mode of hGH administration, blood and urine were sampled at 0900 hours after overnight fasting. Blood glucose, plasma insulin, plasma IGF-1 and plasma total IGF (after extraction) were analysed in blood samples. IGF-1 and hGH were measured in urine samples. These measurements indicated that the dose studied was close to a replacement one, but might be slightly higher than the exact replacement dose.
在25例长期接受人生长激素（hGH）治疗的hGH缺乏患者中，hGH给药方式从传统方法（0.3 - 0.5国际单位/千克/周，分两到三次肌肉注射）改为每天19:00 - 21:00皮下注射，剂量为0.46 ± 0.07国际单位/千克/周（相当于14.7 ± 2.0国际单位/平方米/周）。在采用这种新的hGH给药方式1 - 3个月后，过夜禁食后于09:00采集血样和尿样。分析血样中的血糖、血浆胰岛素、血浆胰岛素样生长因子-1（IGF-1）和血浆总IGF（提取后）。测量尿样中的IGF-1和hGH。这些测量结果表明，所研究的剂量接近替代剂量，但可能略高于确切的替代剂量。
