Norsted T, Jonzon A, Sedin G
Acta Anaesthesiol Scand. 1985 May;29(4):418-23. doi: 10.1111/j.1399-6576.1985.tb02227.x.
To investigate how continuous positive airway pressure (CPAP) changes the vagal nerve activity and whether CPAP alters the efferent phrenic nerve activity or the breathing pattern similarly before and after vagotomy, a study was made of vagal and phrenic nerve activity in chloralose-anaesthetized cats. In the vagal nerve, CPAP increased the mean impulse frequency during expiratory rest. The breath-related impulse frequency also increased with CPAP. With higher CPAP (greater than or equal to 0.5 kPa), the peak of breath-induced activity in the vagal nerve lasted longer than inspiration. In the phrenic nerve, the impulse frequency in the bursts increased almost linearly with CPAP irrespective of whether the vagal nerves were intact or not. The duration of the phrenic nerve bursts decreased with increasing CPAP when the vagal nerves were intact. When the vagal nerves were cut, the burst duration did not change. The rate of breathing was almost unchanged by CPAP regardless of whether the vagal nerves were cut or not. The inspiration/expiration ratio decreased with increasing CPAP when the vagal nerves were intact, but not when they were cut.
为了研究持续气道正压通气（CPAP）如何改变迷走神经活动，以及在迷走神经切断前后CPAP是否类似地改变传出膈神经活动或呼吸模式，对水合氯醛麻醉的猫的迷走神经和膈神经活动进行了研究。在迷走神经中，CPAP增加了呼气暂停期间的平均冲动频率。与呼吸相关的冲动频率也随CPAP增加。使用较高的CPAP（大于或等于0.5 kPa）时，迷走神经中呼吸诱发活动的峰值持续时间比吸气持续时间更长。在膈神经中，无论迷走神经是否完整，爆发中的冲动频率几乎随CPAP呈线性增加。当迷走神经完整时，膈神经爆发的持续时间随CPAP增加而减少。当迷走神经被切断时，爆发持续时间没有变化。无论迷走神经是否被切断，CPAP对呼吸频率几乎没有影响。当迷走神经完整时，吸气/呼气比率随CPAP增加而降低，但当迷走神经被切断时则不然。
